1H-Indene-1,3(2H)-dione,2-(2,4,6-trimethylphenyl)-

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Names

[ CAS No. ]:
15433-03-1

[ Name ]:
1H-Indene-1,3(2H)-dione,2-(2,4,6-trimethylphenyl)-

[Synonym ]:
2-mesitylindane-1,3-dione
2-Mesityl-indan-1,3-dion

Chemical & Physical Properties

[ Density]:
1.177g/cm3

[ Boiling Point ]:
450ºC at 760 mmHg

[ Molecular Formula ]:
C18H16O2

[ Molecular Weight ]:
264.31800

[ Flash Point ]:
167.7ºC

[ Exact Mass ]:
264.11500

[ PSA ]:
34.14000

[ LogP ]:
3.77460

[ Vapour Pressure ]:
2.73E-08mmHg at 25°C

[ Index of Refraction ]:
1.607

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK8390650
CHEMICAL NAME :
1H-Indene-1,3(2H)-dione, 2-(2,4,6-trimethylphenyl)-
CAS REGISTRY NUMBER :
15433-03-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H16-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
35ZRAG "Medicinal Chemistry, Proceedings of the International Symposium on Medicinal Chemistry, Main Lectures, 4th, Noordwijkerhout, Netherlands, 1974," Maas, J., ed., New York, Elsevier Science Pub. Co., 1974 Volume(issue)/page/year: 4,143,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 21,26,1987

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Phthalide
  • Mesitaldehyde
  • Mesitylene
  • 1,3-INDANDIONE
  • bis(2,4,6-trimethylphenyl)iodanium,chloride

DownStream

  • [3-oxo-2-(2,4,6-trimethylphenyl)inden-1-yl] dodecanoate
  • [3-oxo-2-(2,4,6-trimethylphenyl)inden-1-yl] propan-2-yl carbonate
  • [3-oxo-2-(2,4,6-trimethylphenyl)inden-1-yl] 2,2-dimethylpropanoate

Related Compounds

  • 1H-Isoindole-1,3(2H)-dione, 2-[(2,4,6-trimethylphenyl)methyl]-
  • 1H-Indene-1,3(2H)-dione,2-[2-(4-methylphenyl)diazenyl]-
  • 1H-Indene-1,3(2H)-dione, 2-(2,4-dimethylphenyl)-
  • 2-(2,4-dihydroxy-6-methylphenyl)-2-hydroxyindene-1,3-dione
  • 2-(2,4-dimethylphenyl)-3a,4,5,6,7,7a-hexahydroindene-1,3-dione
  • 2-(2,4-DICHLOROBENZYLIDENE)-1H-INDENE-1,3(2H)-DIONE
  • N-(pyridin-3-yl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • N-(isoxazol-3-yl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • N-(5-methyl-1,3,4-thiadiazol-2-yl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • N-(3-methoxybenzyl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • N-(2,6-difluorobenzyl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • (4-(3-methoxyphenyl)piperazin-1-yl)(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-3-yl)methanone
  • N-(1-benzylpiperidin-4-yl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • N-(2-amino-2-oxoethyl)-6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamide
  • (4-(pyrimidin-2-yl)piperazin-1-yl)(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-3-yl)methanone
  • ethyl 4-(6-((tetrahydro-2H-pyran-4-yl)oxy)nicotinamido)piperidine-1-carboxylate
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