6-(trifluoromethyl)pyrimidin-4-ol
Suppliers
Names
[ CAS No. ]:
1546-78-7
[ Name ]:
6-(trifluoromethyl)pyrimidin-4-ol
[Synonym ]:
6-(Trifluoromethyl)-4(1H)-pyrimidinone
4-Hydroxy-6-(trifluoromethyl)pyrimidine
4-Pyrimidinol, 6-(trifluoromethyl)-
4-Hydroxy-6-(trifluoromethyl)pyrimidine
6-TrifluoroMethyl-4-pyriMidinol
6-(trifluoromethyl)-1H-pyrimidin-4-one
6-(trifluoromethyl)pyrimidin-4-ol
MFCD00192530
4-Hydroxy-6-trifluoromethylpyrimidine
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
229.0±35.0 °C at 760 mmHg
[ Melting Point ]:
169-171 °C(lit.)
[ Molecular Formula ]:
C5H3F3N2O
[ Molecular Weight ]:
164.085
[ Flash Point ]:
92.3±25.9 °C
[ Exact Mass ]:
164.019745
[ PSA ]:
46.01000
[ LogP ]:
0.74
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.456
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2933599090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 14(21) , 7175-82, (2006)
In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell li...