Bimatoprost

Suppliers

Names

[ Name ]:
Bimatoprost

[Synonym ]:
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide
BiMatoprost HOUSE STANDARD
BiMapnost
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
Prostamide
17-Phenyl-tri-norprostaglandin F2α-ethyl amide
MFCD03411999
5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-
Lumigan
Bimatoprost

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
629.8±55.0 °C at 760 mmHg

[ Melting Point ]:
66-68°C

[ Molecular Formula ]:
C₂₅H₃₇NO₄

[ Molecular Weight ]:
415.566

[ Flash Point ]:
334.7±31.5 °C

[ Exact Mass ]:
415.272247

[ PSA ]:
89.79000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Propylamine
Bimatoprost isopropyl ester
CHEMPACIFIC 59929
(5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide
Ethylamine
Bimatoprost acid
Bimatoprost acid methyl ester
(4-Carboxybutyl)triphenylphosphonium bromide

DownStream

Articles

A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.

Dermatol. Surg. 40(10) , 1118-24, (2014)

The efficacy and safety of bimatoprost ophthalmic solution 0.03% for treating hypotrichosis were shown in a randomized controlled trial and in an open-label study. To date, no data on real-world exper...

Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study.

PLoS ONE 7 , e33913, (2012)

Conjunctiva-associated lymphoid tissue (CALT) is closely associated with ocular surface immunity. This study investigated the effects of antiglaucoma prostaglandin analogs with or without benzalkonium...

Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes.

Mol. Vis. 18 , 431-8, (2012)

To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes.Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 ...