Metixene hydrochloride

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Names

[ CAS No. ]:
1553-34-0

[ Name ]:
Metixene hydrochloride

[Synonym ]:
methypranol
Trimepranol
metipranolol
Turoptin
1-Methyl-3-thioxanthen-9-ylmethyl-piperidin,Hydrochlorid
Methixenhydrochlorid
metipronalol
Metixene hydrochloride
OptiPranolol
1-methyl-3-thioxanthen-9-ylmethyl-piperidine,hydrochloride
Disorat
Metipranololum
methixene hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
419.7ºC at 760 mmHg

[ Molecular Formula ]:
C20H24ClNS

[ Molecular Weight ]:
345.93

[ Flash Point ]:
207.6ºC

[ Exact Mass ]:
345.13200

[ PSA ]:
28.54000

[ LogP ]:
5.75490

[ Vapour Pressure ]:
2.99E-07mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN1944000
CHEMICAL NAME :
Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-, hydrochloride
CAS REGISTRY NUMBER :
1553-34-0
LAST UPDATED :
198812
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C20-H23-N-S.Cl-H
MOLECULAR WEIGHT :
345.96
WISWESSER LINE NOTATION :
T C666 BS IHJ I1- CT6NTJ A1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
295 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1519 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 141,331,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
346 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
238 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,568,1964

Precursor & DownStream

Precursor

DownStream

  • 9-[(1-methylpiperidin-3-yl)methyl]-9H-thioxanthene 10,10-dioxide

Related Compounds

  • Metixene hydrochloride hydrate
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • dodecylamine hydrochloride
  • (1R)-1-(2-methyl-3,5-dinitrophenyl)ethan-1-ol
  • N-methyl-1-[2-(morpholin-4-yl)-1,3-thiazol-5-yl]cyclopropan-1-amine
  • N-methyl-1-(3,4,5-trimethoxyphenyl)cyclopropan-1-amine
  • methyl 4-amino-4-(1-methyl-1H-imidazol-4-yl)butanoate
  • 3-(2-tert-butyl-2H-1,2,3,4-tetrazol-5-yl)piperidine
  • 2-(5-Bromopyrimidin-2-yl)-3-chlorophenol
  • 3-(2,6-Dimethoxy-4-methylphenyl)piperidine
  • 2-(3-Chloro-2-hydroxyphenyl)prop-2-enoic acid
  • tert-butyl N-{2-amino-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]propyl}carbamate
  • 4-benzyl-2-(1H-imidazol-4-yl)morpholine
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