Pizotifen

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Names

[ CAS No. ]:
15574-96-6

[ Name ]:
Pizotifen

[Synonym ]:
4-(1-Methyl-4-piperidylidene)-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene
4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
UNII:0BY8440V3N
Piperidine, 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-
Pizotyline
EINECS 239-632-9
Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methyl-
Pizotifen
Sandomigran
4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine
4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine
MFCD00864192

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
436.7±45.0 °C at 760 mmHg

[ Melting Point ]:
140-142°C

[ Molecular Formula ]:
C19H21NS

[ Molecular Weight ]:
295.442

[ Flash Point ]:
217.9±28.7 °C

[ Exact Mass ]:
295.139465

[ PSA ]:
31.48000

[ LogP ]:
6.13

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM7165000
CHEMICAL NAME :
Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4 -ylidene)-1-methyl-
CAS REGISTRY NUMBER :
15574-96-6
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H21-N-S
MOLECULAR WEIGHT :
295.47
WISWESSER LINE NOTATION :
T C576 BY FS&T&J BU- DT6N DYTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
12857 ug/kg/12D-I
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 144,815,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,297,1970

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H361

[ Precautionary Statements ]:
P281

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TM7165000

Articles

Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.

J. Pharm. Biomed. Anal. 111 , 333-43, (2015)

Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a...

Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine.

Mymensingh Med. J. 22(1) , 93-100, (2013)

This intervention study conducted in the Neurology outpatient Department of Mymensingh Medical College Hospital (MMCH) from January 2006 to December 2007 to compare efficacy of amitriptyline, pizotife...

Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.

Eur. J. Pharmacol. 535(1-3) , 234-42, (2006)

This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to interact with vascular alpha1-adrenoceptors...


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Related Compounds

  • Pizotifen
  • Pizotifen malate
  • pizotifen maleate
  • Pizotifen hydrochloride
  • 1-(5-Methyl-2-pyridin-2-ylpyrazol-3-yl)piperazine
  • 2-Methyl-5-(thiomorpholine-4-carbonyl)phenol
  • 1-[2-(4-Chlorophenyl)-5-methylpyrazol-3-yl]piperazine
  • 1-(5-Methyl-2-pyridin-4-ylpyrazol-3-yl)piperazine
  • 3-Ethylideneazetidine
  • 1-Tert-butoxycarbonyl-4-(4-trifluoromethyl-2-nitrophenyl)aminopiperidine
  • N-dipyrrolidin-1-ylphosphoryl-N-methylmethanamine
  • 2-Chloro-8-methoxy-4-(trifluoromethyl)quinoline
  • (2-Chloro-6-nitrophenyl)methanamine hydrochloride
  • 1-(3-Hydroxyphenyl)-3-propylurea
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