GTS-21

Suppliers

Names

[ Name ]:
GTS-21

[Synonym ]:
3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride
3-(2,4-dimethoxybenzylidene)anabaseine
2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, (3E)-
3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine
(3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine
3-(2,4)-DiMethoxybenzylidineanabaseine
GTS-21
DMXB-A
GTS 21 2HCl
GTS-21 (dihydrochloride)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
485.6±45.0 °C at 760 mmHg

[ Melting Point ]:
216-217℃ (decomposition)

[ Molecular Formula ]:
C₁₉H₂₂Cl₂N₂O₂

[ Molecular Weight ]:
381.30

[ Flash Point ]:
247.5±28.7 °C

[ PSA ]:
43.71000

[ LogP ]:
2.64

[ Appearance of Characters ]:
powder,faint yellow to dark yellow

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: >5mg/mL

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DW1764860

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25- T cells in experimental colitis.

PLoS ONE 9(10) , e109272, (2014)

The cholinergic anti-inflammatory pathway (CAP) is based on vagus nerve (VN) activity that regulates macrophage and dendritic cell responses in the spleen through alpha-7 nicotinic acetylcholine recep...

Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Br. J. Pharmacol. 172 , 5123-35, (2015)

α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro-cognitive activity of selective α7-nAChR ligands, i...

The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.

J. Neuroimmunol. 251(1-2) , 65-72, (2012)

The anti-inflammatory properties of, particularly the α7, nicotinic acetylcholine receptors (nAChRs) in the peripheral immune system are well documented. There are also reports of anti-inflammatory ac...

GTS-21
(16α)-21-Chloro-17-[(2-furanylcarbonyl)oxy]-16-Methyl-pregna-1,4-diene-3,11,20-trione
(S)-21-Hydroxy-3-methylheneicosansaeure
5-21-04-00366 (Beilstein Handbook Reference)
13,21-Dihydroeurycomanone
11,21-dimethylhentriacontane
[2,2-Dimethyl-1-(2-methylbutan-2-yl)cyclopropyl]methanol
6-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyhexanal
3,3-Difluoro-1-(3-fluoropyridin-4-yl)cyclobutan-1-amine
3-Methylidene-4-propylheptan-1-amine
3-(3-Hydroxythiolan-3-yl)piperidine-3-carboxylic acid
2,2-difluoro-1-(1-methyl-1H-indol-2-yl)ethan-1-one
3-(1-Methylpyrrolidin-2-yl)propane-1,2-diol
2-Methyl-1-(1-methylpyrrolidin-2-yl)propan-2-ol
2-(3-Amino-1-fluoropropyl)-6-chlorophenol
3,3-Dimethyl-5-(morpholin-4-yl)pentanoic acid

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