Licofelone

Suppliers

Names

[ CAS No. ]:
156897-06-2

[ Name ]:
Licofelone

[Synonym ]:
Licofelone
ML-3000
[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
2-[2-(4-Chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
539.7±50.0 °C at 760 mmHg

[ Melting Point ]:
162-163ºC

[ Molecular Formula ]:
C23H22ClNO2

[ Molecular Weight ]:
379.879

[ Flash Point ]:
280.2±30.1 °C

[ Exact Mass ]:
379.133911

[ PSA ]:
42.23000

[ LogP ]:
6.73

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY7759650
CHEMICAL NAME :
1H-Pyrrolizine-5-acetic acid, 2,3-dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-
CAS REGISTRY NUMBER :
156897-06-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H22-Cl-N-O2
MOLECULAR WEIGHT :
379.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg/11D-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from duodenum
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1329,1994

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

  • Oxalyl chloride
  • 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE
  • methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate
  • 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole
  • 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide
  • 2-Bromo-4'-chloroacetophenone
  • 2,2-dimethyl-7-phenyl-2,3,5,6-tetrahydro-1H-pyrrolizin-6-one

DownStream

Related Compounds

  • Licofelone-d6
  • Licofelone-d4
  • Licofelone,ML-3000
  • Licofelone Acyl--D-glucuronide
  • N-(2-(6-(ethylthio)-4-(isopropylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-naphthamide
  • 1-(3-methylbenzyl)-3-(pyridin-2-ylmethyl)pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
  • 5-[6-hydroxy-5-[(E)-4-hydroxy-3-methylbut-2-enyl]-1-benzofuran-2-yl]benzene-1,3-diol
  • 9(10H)-Acridinone, 2-ethoxy-6-nitro-
  • CID 10913123
  • (2R)-2-amino-N-(2-phenylethyl)propanamide
  • kaempferol-3-O-(2-O-acetyl-alpha-L-rhamnopyranoside)
  • 3,4-dihydro-6-hydroxy-3-(1-phenylmethyl-4-piperidinyl)-2(1H)-quinazolinone
  • Perfluoro(N-hexylpiperidine)
  • Perfluorodecahydro-2-n-butylnaphthalene
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