8-Hydroxyquinoline-2-Carboxylic Acid

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Names

[ CAS No. ]:
1571-30-8

[ Name ]:
8-Hydroxyquinoline-2-Carboxylic Acid

[Synonym ]:
8-hydroxyquinoline-2-carboxylic acid
8-Hydroxy-2-quinolinecarboxylic acid
2-Quinolinecarboxylic acid, 8-hydroxy-
MFCD00168972
Quinaldic acid, 8-hydroxy-
8-Hydroxyquinaldic acid

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
426.7±30.0 °C at 760 mmHg

[ Melting Point ]:
213-214 °C

[ Molecular Formula ]:
C10H7NO3

[ Molecular Weight ]:
189.167

[ Flash Point ]:
211.9±24.6 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
70.42000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.730

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UZ9450000
CHEMICAL NAME :
Quinaldic acid, 8-hydroxy-
CAS REGISTRY NUMBER :
1571-30-8
BEILSTEIN REFERENCE NO. :
0146082
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H7-N-O3
MOLECULAR WEIGHT :
189.18
WISWESSER LINE NOTATION :
T66 BNJ CVQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 108,924,1963 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UZ9450000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Methylquinolin-8-ol
  • 8-hydroxyquinoline-2-carbonitrile
  • 8-Methoxyquinoline-2-carboxylic acid
  • 8-Methoxy-2-methylquinoline
  • 8-Quinolinol 1-oxide
  • 8-hydroxy-1-methoxyquinolin-1-ium methyl sulfate
  • 5-bromo-8-methoxyquinoline-2-carboxylic acid
  • (E)-8-methoxy-2-styrylquinoline
  • Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate

DownStream

  • Benzyl 8-hydroxyquinoline-2-carboxylate
  • 2-Quinolinecarbonyl chloride, 8-hydroxy- (9CI)
  • methyl 8-hydroxyquinoline-2-carboxylate
  • 8-acetyloxyquinoline-2-carboxylic acid

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 7-Bromo-8-hydroxyquinoline-2-carboxylic acid
  • 8-hydroxyquinoline-2-carboxylic acid chloride
  • 8-hydroxyquinoline-2-carboxylic acid chloride
  • diphenylboron,8-hydroxyquinoline-2-carboxylic acid
  • 8-Fluoro-4-hydroxyquinoline-2-carboxylic acid
  • 8-Bromo-4-hydroxyquinoline-2-carboxylic acid
  • 6-amino-2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one
  • 4-[4-(Propan-2-yloxy)phenyl]-1,3-oxazolidin-2-one
  • 2,2',2''-(10-(((2,2-Diphosphonoethyl)(hydroxy)phosphoryl)methyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
  • N-(3-ethylphenyl)thian-3-amine
  • 1-[2-(3-Bromo-5-methylthiophen-2-yl)ethyl]cyclopropan-1-amine
  • 1-(3-Amino-3-methylazetidin-1-yl)ethan-1-one
  • 3-Cyano-1-iodomethylnaphthalene
  • 2-(Pyrimidin-2-ylamino)propane-1,3-diol
  • 6-(Hydrazinylmethyl)-2-methylquinoline
  • (2R)-2-amino-3-(dimethylcarbamoyl)propanoic acid