4-(hydroxymethyl)-d-phenylalanine

Names

[ Name ]:
4-(hydroxymethyl)-d-phenylalanine

[Synonym ]:
(R)-2-Amino-3-[4-(hydroxymethyl)phenyl]propionic acid
4-(Hydroxymethyl)-D-phenylalanine
D-Phenylalanine,4-(hydroxymethyl)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₃NO₃

[ Molecular Weight ]:
195.21500

[ Exact Mass ]:
195.09000

[ PSA ]:
83.55000

[ LogP ]:
0.83360

[ Vapour Pressure ]:
5.14E-07mmHg at 25°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Tetrapeptide tyrosine kinase inhibitors. Enantioselective synthesis of p-hydroxymethyl-L-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-L-phenylalanine.

Int. J. Pept. Protein Res. 44(5) , 457-65, (1994)

A convenient enantioselective synthesis of p-hydroxymethyl-L-phenylalanine was developed which produces a 4/1 ratio of L/D enantiomers resulting from a chiral phase-transfer-catalyzed alkylation. This...

Analogs of arginine vasopressin modified in position 3 with (R)-alpha-hydroxymethylphenylalanine.

J. Pept. Res. 53(5) , 554-9, (1999)

This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe...

DALDA analogues containing alpha-hydroxymethylamino acids.

Acta Biochim. Pol. 48(4) , 1121-4, (2001)

To evaluate the role of aromatic amino-acids residues, four analogues of the mu-selective opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphiphilic, a,a-disubstituted amino aci...

4-hydroxymethyl-phenylalanine
(S)-α-(hydroxymethyl)-D-phenylalanine
4-hydroxymethyl-L-phenylalanine
4-Nitro-D-phenylalanine methyl ester monohydrochloride
4-Methyl-D-phenylalanine
4-Azido-D-phenylalanine
2-{[3,5-dimethyl-1-(3-methylbutanoyl)-1H-pyrazol-4-yl]sulfonyl}-1,2,3,4-tetrahydroisoquinoline
2-{[3,5-dimethyl-1-(4-methylbenzoyl)-1H-pyrazol-4-yl]sulfonyl}-1,2,3,4-tetrahydroisoquinoline
1-[3,5-dimethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)-1H-pyrazol-1-yl]-2-(4-methoxyphenoxy)ethan-1-one
N,N-diethyl-3,5-dimethyl-1-(2-oxo-2H-chromene-3-carbonyl)-1H-pyrazole-4-sulfonamide
1-{4-[(Diethylamino)sulfonyl]-3,5-dimethylpyrazolyl}-2-[4-(tert-butyl)phenoxy] ethan-1-one
N-(2-((4-(3-chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)-2-propylpentanamide
N-(2-((4-(2-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-3-methylbutanamide
N-(2-((4-(2-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-4-isopropoxybenzamide
N-(2-((4-(2-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-2-(thiophen-2-yl)acetamide
2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide

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