5-Chlorovaleryl chloride

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Names

[ CAS No. ]:
1575-61-7

[ Name ]:
5-Chlorovaleryl chloride

[Synonym ]:
5-Chlorovaleryl chloride
MFCD00000758
5-Chloropentanoyl chloride
Pentanoyl chloride, 5-chloro- (9CI)
Pentanoyl chloride, 5-chloro-
5-Chlorovaleroyl chloride
EINECS 216-403-1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
188.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C5H8Cl2O

[ Molecular Weight ]:
155.022

[ Flash Point ]:
76.3±22.9 °C

[ Exact Mass ]:
153.995224

[ PSA ]:
17.07000

[ LogP ]:
1.87

[ Vapour Pressure ]:
0.6±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.446

[ Water Solubility ]:
reacts

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV9108000
CHEMICAL NAME :
Valeryl chloride, 5-chloro-
CAS REGISTRY NUMBER :
1575-61-7
BEILSTEIN REFERENCE NO. :
1745182
LAST UPDATED :
199706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H8-Cl2-O
MOLECULAR WEIGHT :
155.03
WISWESSER LINE NOTATION :
GV4G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02242

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;C:Corrosive;

[ Risk Phrases ]:
R22;R23;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
YV9108000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloropentanoic acid
  • delta-Valerolactone
  • phosgene
  • 3-Mepy
  • 1,3,4-trimethylimidazolidin-2-one
  • mepiquat chloride
  • Valeryl chloride
  • 5-Chlorovaleronitrile
  • Chlorine
  • benzene

DownStream

  • 1-(4-Nitrophenyl)-2-piperidinone
  • 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
  • 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone
  • 5-CHLORO-1-(4-METHYLPHENYL)-1-OXOPENTANE
  • 5-CHLORO-1-(4-FLUOROPHENYL)-1-OXOPENTANE
  • 5-chloro-1-phenylpentan-1-one
  • 5-CHLORO-1-(4-CHLOROPHENYL)-1-OXOPENTANE
  • 5-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPENTANE
  • 2-(2-methylpropyl)oxane
  • 6H-benzo[h][1,6]naphthyridin-5-one

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Development and validation of a specific and sensitive GC-FID method for the determination of impurities in 5-chlorovaleroyl chloride.

J. Pharm. Biomed. Anal. 53(3) , 309-14, (2010)

5-Chlorovaleroyl chloride (5-CVC) is commonly used as an alkylating agent in the synthesis of pharmaceutical intermediates, active ingredients, as well as other specialty chemicals. It is critical to ...

Effect of the acylating agent on the selectivity of anion-exchange resins and separation efficiency. Kas'yanova TN, et al.

Moscow Univ. Chem. Bull. 62(5) , 286-89, (2007)


More Articles

Related Compounds

  • 2-ethyl-5-chlorovaleryl chloride
  • 3-(5-chlorovaleryl)-4(S)-isopropyl-1,3-thiazolidine-2-thione
  • 2-(5-CHLOROVALERYL)OXAZOLE
  • 2,2,4-trimethyl-glutaric acid-5-chloride-1-methyl ester
  • pentaamminechlororuthenium
  • 4-CHLORO-PENTANOYL CHLORIDE
  • 2-(Bromomethyl)-6-(difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine
  • 2-(Chloromethyl)-6-(difluoromethyl)-5-methylpyridine-3-carboxaldehyde
  • 2-(Chloromethyl)-3-(difluoromethyl)-4-fluoro-5-nitropyridine
  • 2-(Chloromethyl)-3-(difluoromethyl)-4-methyl-5-nitropyridine
  • 2-(Chloromethyl)-4-(difluoromethyl)-5-(trifluoromethoxy)pyridine-3-carboxaldehyde
  • 2-(Bromomethyl)-6-(difluoromethyl)-5-fluoro-3-iodopyridine
  • 2-(Chloromethyl)-3-(difluoromethyl)-6-methyl-5-nitropyridine
  • Ethyl 3-cyano-1-methylcyclobutanecarboxylate
  • 2-(Chloromethyl)-3-(difluoromethyl)-5-iodo-4-(trifluoromethyl)pyridine
  • 2-(Chloromethyl)-5-(difluoromethyl)-3-hydroxypyridine
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