4-Methylbenzenesulfonhydrazide

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Names

[ CAS No. ]:
1576-35-8

[ Name ]:
4-Methylbenzenesulfonhydrazide

[Synonym ]:
4-Methylbenzenesulfo
Foamer TSH
Tosylhydrazine
4-methylbenzenesulfonylhydrazide
TSH
BlowingagentTSH
p-Toluenesulfonyl hydrazide
4-Toluenesulphonyl hydrazide
p-Toluenesulfonic acid, hydrazide (8CI)
EINECS 216-407-3
1-Tosylhydrazine
Benzenesulfonic acid, 4-methyl-, hydrazide
MFCD00007588
p-Toluenesulfonhydrazide
toluene-4-sulfonic acid hydrazide
4-Methylbenzenesulfonohydrazide
P-TOLYL HYDRAZIDE
(p-Tolylsulfonyl)hydrazine
p-toluenesulfonic hydrazide
p-toluenesulfonohydrazide
PTSH
Tosylhydrazide
toluene-4-sulfonhydrazide
Posaconazole Impurity 53

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
340.5±35.0 °C at 760 mmHg

[ Melting Point ]:
103-108 °C(lit.)

[ Molecular Formula ]:
C7H10N2O2S

[ Molecular Weight ]:
186.232

[ Flash Point ]:
159.7±25.9 °C

[ Exact Mass ]:
186.046295

[ PSA ]:
80.57000

[ LogP ]:
0.32

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
Flammables area

[ Water Solubility ]:
5 g/L (15 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MW0210000
CHEMICAL NAME :
Hydrazine, p-tolylsulfonyl-
CAS REGISTRY NUMBER :
1576-35-8
BEILSTEIN REFERENCE NO. :
0610130
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H10-N2-O2-S
MOLECULAR WEIGHT :
186.25
WISWESSER LINE NOTATION :
ZMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 36,27,1973

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H242-H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
F:Flammable;Xn:Harmful;

[ Risk Phrases ]:
R11;R22;R44

[ Safety Phrases ]:
S16

[ RIDADR ]:
UN 3226 4.1

[ WGK Germany ]:
3

[ RTECS ]:
MW0210000

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

[ HS Code ]:
29280090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Tosyl chloride
  • Benzenesulfonic acid,4-methyl-, 2-(phenylmethylene)hydrazide
  • Hydrazine hydrate
  • Ethanol

DownStream

  • N-[(E)-indeno[2,1-b]pyridin-9-ylideneamino]-4-methylbenzenesulfonamide
  • 5-Amino-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole-4-carbonitrile
  • N'-(5,5-dimethyl-3-oxocyclohexen-1-yl)-4-methylbenzenesulfonohydrazide
  • 4-Methylbenzenesulfonhydrazide-d3
  • 2-(p-toluenesulfonyl)acetophenone
  • 2-hydroxy-2-phenylethyl 4-methylphenyl sulfone
  • acetophenone tosylhydrazone
  • benzophenone tosylhydrazone 97
  • (E)-2-(2-TOSYLHYDRAZONO)ACETYL CHLORIDE

Customs

[ HS Code ]: 29280090

Articles

Protecting group free glycosidations using p-toluenesulfonohydrazide donors.

Org. Lett. 10(16) , 3461-3, (2008)

N'-Glycopyranosylsulfonohydrazides are introduced as glycosyl donors for protecting group free synthesis of O-glycosides, glycosyl azides, and oxazolines. Mono- and disaccharides containing a reducing...

Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity.

Eur. J. Med. Chem. 45(11) , 5080-5, (2010)

A series of novel p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles derivatives (2a-f, 3a-f and 5-8) were synthesized by initial condensation of p-toluenesulfonylthiosemicarbazide 1 wit...

Vasoconstrictor-induced changes in renal blood flow: role of prostaglandins and histamine.

Am. J. Physiol. 254(4 Pt 2) , F470-6, (1988)

The role of histamine (H) and prostaglandins (PGs) in the renal vasoconstriction prompted by a 10-min intrarenal infusion of norepinephrine (NE, 0.2 micrograms), antidiuretic hormone (ADH, 10 mU), or ...


More Articles

Related Compounds

  • 4-Methylbenzenesulfonhydrazide-d3
  • 4-Amino-2-chloro-5-(1H-tetrazol-5-yl)benzenesulfonamide
  • 4-(4-Chlorophenyl)-4-Bromopiperide
  • 4-(2-nitroimidazol-1-yl)butane-1,2-diol
  • 4-Iodo-1H-indazole-3-carboxylic acid
  • 4-chlorooxolan-3-ol,formic acid