N4-OCTADECYLCYTOSINE BETA-D-ARABINOFURANOSIDE

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Names

[ CAS No. ]:
158233-67-1

[ Name ]:
N4-OCTADECYLCYTOSINE BETA-D-ARABINOFURANOSIDE

[Synonym ]:
N(4)-octadecyl-ara-C,N4-Stearyl-Ara C,NOAC
N4-Stearyl-Ara C
NOAC
N(4)-octadecyl-ara-C
N(4)-Octadecyl-1-arabinofuranosylcytosine
Alkasar-18

Chemical & Physical Properties

[ Density]:
1.16g/cm3

[ Boiling Point ]:
643ºC at 760mmHg

[ Molecular Formula ]:
C27H49N3O5

[ Molecular Weight ]:
495.69500

[ Flash Point ]:
342.7ºC

[ Exact Mass ]:
495.36700

[ PSA ]:
120.33000

[ LogP ]:
4.36240

[ Vapour Pressure ]:
3.01E-19mmHg at 25°C

[ Index of Refraction ]:
1.556

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UW7370900

Articles

Metabolism of the new liposomal anticancer drug N4-octadecyl-1-beta-D-arabinofuranosylcytosine in mice.

Drug Metab. Dispos. 27 , 342-350, (1999)

Metabolism and excretion of the new antitumor drug N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) was investigated in mice. Mice were injected i.v. with tritium-labeled liposomal NOAC (4 microm...

Lipophilic arabinofuranosyl cytosine derivatives in liposomes.

Meth. Enzymol. 391 , 58-70, (2005)

Highly lipophilic drugs can be used therapeutically only by the addition of possibly toxic solubilizing agents or by development of complex pharmaceutical formulations. One way of overcoming these dis...

In vitro activity of liposomal N4octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC), a new lipophilic derivative of 1-beta-D-arabinofuranocylcytosine on biopsized clonogenic human tumor cells and hematopoietic precursor cells.

Invest. New Drugs 19 , 203-210, (2001)

N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) is a new lipophilic derivative of 1-beta-D-arabinofuranosylcytosine (ara-C) with potent antitumor activity against leukemias and solid tumors. In ...


More Articles

Related Compounds

  • hypoxanthine-9-beta-d-arabinofuranoside
  • CYTOSINE BETA-D-ARABINOFURANOSIDE HYDROCHLORIDE
  • Thymine-beta-D-arabinofuranoside
  • D-Arabinofuranoside, Methyl, triacetate
  • 4-METHYLUMBELLIFERYL BETA-D-N,N'-DIACETYL-CHITOBIOSIDE
  • 11-KETOANDROSTERONE BETA-D-GLUCURONIDE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • N,N-Diethyl-2-methyl-1H-benzimidazole-6-sulfonamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide