distigmine bromide
Suppliers
Names
[ CAS No. ]:
15876-67-2
[ Name ]:
distigmine bromide
[Synonym ]:
Distigminbromid
EINECS 240-013-0
Distigmindibromid
Bromure de distigmine [INN-French]
Hexamethylenebis[N-methylcarbaminoyl-1-methyl-3-hydroxypyridinium Bromide]
Hexamethylenebis[methylcarbamic Acid] Ester of 3-Hydroxy-1-methylpyridinium Bromide
3,3'-{Hexane-1,6-diylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridinium) dibromide
Ubretid
Distigmine
3,3'-{1,6-Hexanediylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridinium) dibromide
N,N'-Dimethyl-N,N'-bis-(1-methyl-pyridinium-3-yloxycarbonyl)-hexandiyldiamin,Dibromid
N,N'-dimethyl-N,N'-bis-(1-methyl-pyridinium-3-yloxycarbonyl)-hexanediyldiamine,dibromide
Hexamethylenebis[N-methylcarbamic Acid Ester Bromomethylate]
Hexamarium
Pyridinium, 3,3'-[1,6-hexanediylbis[(methylimino)carbonyloxy]]bis[1-methyl-, bromide (1:2)
3-Hydroxy-1-methylpyridinium Bromide Hexamethylenebis[methylcarbamate]
Ubritil
distigmine bromide
BC 51
Distigmini bromidum [INN-Latin]
Bromuro de distigmina [INN-Spanish]
3,3'-[1,6-Hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methylpyridinium]dibromide
Chemical & Physical Properties
[ Molecular Formula ]:
C22H32Br2N4O4
[ Molecular Weight ]:
576.32
[ Exact Mass ]:
574.079041
[ PSA ]:
66.84000
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU5277000
- CHEMICAL NAME :
- Pyridinium, 3-hydroxy-1-methyl-, bromide, hexamethylenebis(methylcarbamate)
- CAS REGISTRY NUMBER :
- 15876-67-2
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C22-H32-N4-O4.2Br
- MOLECULAR WEIGHT :
- 576.40
- WISWESSER LINE NOTATION :
- T6KJ A1 COVN1&6N1&VO- DT6KJ A1 &E 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 900 ug/kg/3D
- TOXIC EFFECTS :
- Autonomic Nervous System - parasympatholytic Vascular - other changes Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,383,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 700 ug/kg/7D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford St., London WC2E 9HD, UK) V.10(10)- 1956- Volume(issue)/page/year: 48,103,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 740 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1080 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 740 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969