Everolimus (RAD001)

Suppliers

Names

[ CAS No. ]:
159351-69-6

[ Name ]:
Everolimus (RAD001)

[Synonym ]:
SDZRAD
Certican
Zortress
Afinitor
RAD-001
CERTICAN(R)
42-O-(2-Hydroxyethyl)-rapamycin
Everolimus
Certica

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
998.7±75.0 °C at 760 mmHg

[ Melting Point ]:
NA

[ Molecular Formula ]:
C₅₃H₈₃NO₁₄

[ Molecular Weight ]:
958.224

[ Flash Point ]:
557.8±37.1 °C

[ Exact Mass ]:
957.581360

[ PSA ]:
204.66000

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
−20°C

[ Stability ]:
Hygroscopic

[ Water Solubility ]:
Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H332-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R48/25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 1648 3 / PGII

[ WGK Germany ]:
2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis.

Antimicrob. Agents Chemother. 59(2) , 1088-99, (2015)

Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus, and infections with this virus can result in acute respiratory syndrome with renal failure. Globally, MERS-CoV h...

Deproteination of whole blood for LC–MS/MS using paramagnetic micro-particles

Clin. Biochem. 47(15) , 112-5, (2014)

Objectives Liquid chromatography tandem mass spectrometry has become increasingly popular in clinical laboratories over the last decade due to the inherent sensitivity and specificity of the technolog...

A direct method for the measurement of everolimus and sirolimus in whole blood by LC-MS/MS using an isotopic everolimus internal standard.

Ther. Drug Monit. 36(3) , 358-65, (2014)

Whole-blood concentrations of the immunosuppressant drugs everolimus and sirolimus should be monitored. A sensitive and selective method offering the detection of both analytes in small sample volumes...

Everolimus-d4
Everolimus Impurity 4
Everolimus Impurity 3
Everolimus Impurity 23
Everolimus EP Impurity E
chromium cobalt
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3-(2-amino-1H-imidazol-1-yl)-1-ethylpyrrolidin-2-one
1-(propan-2-yl)-5-(4-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}phenyl)-1H-imidazole
methyl N-[(5-bromo-2-hydroxyphenyl)methyl]carbamate
4-chloro-5-cyano-1H-indole-2-carboxylic acid
(9H-fluoren-9-yl)methyl 2-(aminomethyl)-3-fluoropiperidine-1-carboxylate
3-(Chloromethyl)-4-ethylbenzonitrile
1-(Butan-2-yl)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
(2R,4R)-1-(11BS)-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2,4-diphenylazetidine
2-(Iodomethyl)morpholin-3-one

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