[R-(R,S)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride

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Names

[ Name ]:
[R-(R*,S*)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride

[Synonym ]:
D-propoxyphene
2-Butanol,4-(dimethylamino)-3-methyl-1,2-diphenyl-,propionate (ester),hydrochloride,(L)
(2R,3S)-4-Dimethylamino-3-methyl-1,2-diphenyl-2-propionyloxy-butan,Hydrochlorid
L-Propoxyphene hydrochloride
(2R,3S)-4-dimethylamino-3-methyl-1,2-diphenyl-2-propionyloxy-butane,hydrochloride
Levopropoxyphene HCl
[4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate,hydrochloride
Levopropoxyphene hydrochloride
[4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
444ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₃₀ClNO₂

[ Molecular Weight ]:
375.93200

[ Flash Point ]:
130.6ºC

[ Exact Mass ]:
375.19700

[ PSA ]:
29.54000

[ LogP ]:
5.07750

[ Vapour Pressure ]:
4.43E-08mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL3050000

CHEMICAL NAME :: 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), hydrochloride, (L)-

CAS REGISTRY NUMBER :: 1596-70-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H29-N-O2.Cl-H

MOLECULAR WEIGHT :: 375.98

WISWESSER LINE NOTATION :: 2VOXR&1R&Y1&1N1&1 &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,320,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,451,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,319,1970

Related Compounds

8-(chloromethyl)-3-methyl-7-(2-oxo-2-phenylethyl)-1H-purine-2,6(3H,7H)-dione
3-(8-(chloromethyl)-3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)propanenitrile
3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propanoic acid
N-[3-[[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]phenyl]-N-methylacetamide
N-(3-aminophenyl)tetrahydrothiophene-3-carboxamide 1,1-dioxide
3'-(Chloromethyl)-2-methyl-1,1'-biphenyl
Methyl 6-(tert-butyl)-2-chloro-3-cyanoisonicotinate
2-Tert-butyl-6-chloropyridine-4-carboxylic acid
2-((3-(4-Isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-[[3-[3-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-

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