2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-

Names

[ Name ]:
2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-

[Synonym ]:
2,3'-Anhydro-D-thymidine
Anhydrothymidine
2,3'-O-Cyclothymidine
5-methyl-2'-deoxy-2,3'-anhydrouridine
threo-2,3'-anhydro-thymidine
O2,3'-Cyclothymidine

Chemical & Physical Properties

[ Density]:
1.72g/cm3

[ Boiling Point ]:
381.8ºC at 760mmHg

[ Melting Point ]:
246-247ºC

[ Molecular Formula ]:
C₁₀H₁₂N₂O₄

[ Molecular Weight ]:
224.21

[ Flash Point ]:
184.7ºC

[ Exact Mass ]:
208.08500

[ PSA ]:
64.35000

[ Vapour Pressure ]:
2.12E-07mmHg at 25°C

[ Index of Refraction ]:
1.735

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

[3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases].

Bioorg. Khim. 21 , 49-54, (1995)

5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structu...

Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.

Nucleosides Nucleotides Nucleic Acids 27 , 1272-1281, (2008)

A general method is described for synthesizing 3',5'-dithio-2'-deoxypyrimidine nucleosides 6 and 13 from normal 2'-deoxynucleosides. 2,3'-Anhydronucleosides 2 and 9 are applied as intermediates in the...

acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(3H-inden-1-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Gonazon
Cetrotide
1-(1-Benzylpiperidin-4-yl)-3-methylimidazolidin-2-one
5-Chloro-2-[(2,2,2-trifluoroethyl)sulfanyl]aniline
3-(Pyrazin-2-yloxy)phenol
3-Chlorothiophen-2-amine
Alexa Fluor 568 ortho-isomer
Octahydro-1aH-2,5-methanoindeno[1,2-b]oxiren-2-ol
7-Chloro-4-((3-(diethylamino)propyl)amino)-6-nitroquinoline diphosphate

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.