2-Amino-5-methylpyridine

Suppliers

Names

[ Name ]:
2-Amino-5-methylpyridine

[Synonym ]:
2-Amino-5-picoline
6-Amino-3-picoline
2-Amino-5-methylpyridine
5-Methylpyridin-2-amin
MFCD00006328
2-Pyridinamine, 5-methyl-
5-methylpyridin-2-amine
5-Methyl-2-pyridinamine
EINECS 216-503-5

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
227.0±0.0 °C at 760 mmHg

[ Melting Point ]:
76-77 °C(lit.)

[ Molecular Formula ]:
C₆H₈N₂

[ Molecular Weight ]:
108.141

[ Flash Point ]:
110.9±9.0 °C

[ Exact Mass ]:
108.068748

[ PSA ]:
38.91000

[ LogP ]:
1.08

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.574

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ5141000

CHEMICAL NAME :: 3-Picoline, 6-amino-

CAS REGISTRY NUMBER :: 1603-41-4

BEILSTEIN REFERENCE NO. :: 0107050

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H8-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 36,491,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TJ5141000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Bromo-5-picoline
3-picoline n-oxide
2-Chloro-5-methylpyridine
diethyl (2-amino-5-methylpyridin-3-yl)phosphonate
2,2-dimethyl-3-(5-methylpyridin-2-yl)-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one
2-Amino-3-bromo-5-picoline
Diethyl phosphite
N,N-dimethyl-N'-(5-methylpyridin-2-yl)methanimidamide
3-Mepy

DownStream

2-Methylamino-5-methyl-3-nitropyridine
6-Hydroxynicotinic acid
6-Aminonicotinic acid
2-Bromo-5-picoline
Methyl 6-aminonicotinate
6-Aminonicotinamide
6-Fluoronicotinic acid
2-acetamido-5-picoline
5,5′-dicarboxy-2,2′-bipyridine
Zolpidem Carbaldehyde

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%