phosphorodiamidic chloride, tetramethyl-

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Names

[ CAS No. ]:
1605-65-8

[ Name ]:
phosphorodiamidic chloride, tetramethyl-

[Synonym ]:
Phosphoric Acid Bis(dimethylamido) Chloride
N-[chloro(dimethylamino)phosphoryl]-N-methylmethanamine
phosphorodiamidic chloride, tetramethyl-
EINECS 216-517-1
Phosphorodiamidic chloride, N,N,N',N'-tetramethyl-
Bis(diMethylaMino)phosphoryl Chloride
N,N,N',N'-Tetramethylphosphorodiamidic chloride
Bis(dimethylamino)phosphorochloridate
MFCD00008302

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
187.0±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H12ClN2OP

[ Molecular Weight ]:
170.578

[ Flash Point ]:
66.9±22.6 °C

[ Exact Mass ]:
170.037582

[ PSA ]:
33.36000

[ LogP ]:
-1.18

[ Vapour Pressure ]:
0.6±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.462

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • bis(dimethylamino)chlorophosphine
  • Dimethylamine
  • Hexamethylphosphoramide
  • N,N-dibenzyl-O-diphenylphosphinylhydroxylamine
  • Dimethylamidophosphoric dichloride
  • 4-Cyclopentene-1,3-dione,2,2,4,5-tetrachloro-
  • 2-(dichlorophosphoryl)-1,1,1-tris(dimethylamino)-2-oxa-1-phosphaethan-1-ium chloride
  • ((chlorocarbonyl)oxy)tris(dimethylamino)phosphonium chloride

DownStream

  • 2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl N,N,N',N'-Tetramethylphosphorodiamidate
  • Bis(N,N-dimethylamino)-pentachloro-phenyl phosphate
  • Hexamethylphosphoramide
  • DIMEFOX
  • Dimethylamidophosphoric aciddifluoride
  • 4-Oxa-2-aza-3-phospha-5-stannanonan-3-amine,5,5-dibutyl-N,N,2-trimethyl-, 3-oxide (9CI)
  • N-[dimethylamino(ethoxy)phosphoryl]-N-methylmethanamine
  • Dimethylamidophosphoric dichloride

Articles

Total Synthesis of Neohedycaryol. Its Possible Role in the Biosynthesis of Eudesmane Sesquiterpenes.

J. Org. Chem. 62(8) , 2344-2349, (1997)

The total synthesis of neohedycaryol (4), the C(9)-C(10) double bond regioisomer of the germacrane sesquiterpene hedycaryol, was accomplished in 10 steps from the known dione 6. A Marshall fragmentati...

Relative and Absolute Configuration of Allohedycaryol. Enantiospecific Total Synthesis of Its Enantiomer.

J. Org. Chem. 61(12) , 4022-4027, (1996)

The enantiomer of (+)-allohedycaryol, a germacrane alcohol isolated from giant fennel (Ferula communis L.), has been synthesized, thereby elucidating the relative and absolute stereochemistry of the n...

Synthesis and chiroptical properties of a novel C2-symmetric binaphthyl phosphortriamide ("chiral HMPA").

Chirality 9(5-6) , 431-4, (1997)

By use of an asymmetric Ullmann coupling involving chiral naphthalene oxazolines 1, the title compounds were prepared in good yields and with high diastereoselectivity. Hydrolysis of the binaphthyl ox...


More Articles

Related Compounds

  • TETRAMETHYLURONIUM CHLORIDE)
  • Tetramethylammonium-d12 chloride
  • N-[chloro-(N-methylanilino)phosphoryl]-N-methylaniline
  • Phosphorodiamidicchloride, tetrakis(2-chloroethyl)- (9CI)
  • Bis(dimethylamino)chlorophosphine sulfide
  • N,N,N',N'-Tetraethylphosphorodiamidic chloride