4,4,4,4',4',4'-Hexafluoro-DL-valine

Suppliers

Names

[ Name ]:
4,4,4,4',4',4'-Hexafluoro-DL-valine

[Synonym ]:
2-(Difluoroamino)-2,3,4,4-tetrafluoro-3-methylbutanoic acid
EINECS 240-207-5
4,4,4,4′,4′,4′-Hexafluoro-DL-valine
2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric Acid
4,4,4,4',4',4'-Hexafluoro-DL-valine
MFCD00014349
DL-hexafluorovaline
2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric acid 4,4,4,5,5,5-Hexafluoro-DL-valine
hexafluorovaline
2-amino-3-trifluoromethyl-4,4,4-trifluorobutanoic acid

Chemical & Physical Properties

[ Density]:
1.575 g/cm3

[ Boiling Point ]:
165.9ºC at 760 mmHg

[ Melting Point ]:
204°C (dec.)

[ Molecular Formula ]:
C₅H₅F₆NO₂

[ Molecular Weight ]:
225.08900

[ Flash Point ]:
54.1ºC

[ Exact Mass ]:
225.02200

[ PSA ]:
63.32000

[ LogP ]:
1.83940

[ Index of Refraction ]:
1.349

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN3335

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DL-hexafluorovaline benzyl ester
4,4,4,4',4',4'-Hexafluorovaline,ethylester
benzyl β,β-bis(trifluoromethyl)acrylate
ethyl 4,4,4-trifluoro-3-(trifluoromethyl)crotonate
DL-hexafluorovaline benzyl ester hydrochloride
Hexafluorisopropyliden-malonsaeure-diethylester
2-Amino-2-hexafluorisopropyl-malonsaeure-diaethylester
4,4,4-Trifluoro-3-(trifluoromethyl)but-2-enoic acid

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of fluorine-containing peptides. Analogues of angiotensin II containing hexafluorovaline.

J. Med. Chem. 24(9) , 1043-7, (1981)

Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hex...

Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8.

J. Med. Chem. 30(6) , 1097-100, (1987)

An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-H...