2,5-Dichloropyridine

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Names

[ CAS No. ]:
16110-09-1

[ Name ]:
2,5-Dichloropyridine

[Synonym ]:
2,5-Dichlor-pyridin
5-Dichloropyridine
2,3-Dichloropyridine
EINECS 240-278-2
2,4-DIFLUORO-3-METHOXY ACETOPHENONE
2,5-DICHLORPYRIDINE
Dichloropyridine
Pyridine, 2,5-dichloro-
T6NJ BG CG
2,5-dichloro-pyridin
Pyridine,2,5-dichloro
2,5-dibrochloropyridine
3-chloro-6-chloropyridine
Pyridine, 2,3-dichloro-
2,5-Dichloropyridine
2-chloro-5-chloropyridine
5-chloro-2-chloropyridine
MFCD00006239
4-Aminophenylacetamide
2,5-dichloro pyridine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
186.6±20.0 °C at 760 mmHg

[ Melting Point ]:
59-62 °C(lit.)

[ Molecular Formula ]:
C5H3Cl2N

[ Molecular Weight ]:
147.99

[ Flash Point ]:
83.1±7.4 °C

[ Exact Mass ]:
146.964249

[ PSA ]:
12.89000

[ LogP ]:
2.17

[ Vapour Pressure ]:
0.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
Room temperature.

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US8225000
CHEMICAL NAME :
Pyridine, 2,5-dichloro-
CAS REGISTRY NUMBER :
16110-09-1
BEILSTEIN REFERENCE NO. :
0108886
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H3-Cl2-N
MOLECULAR WEIGHT :
147.99
WISWESSER LINE NOTATION :
T6NJ BG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1690 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 11,361,1967

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
US8225000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,5-Dibromopyridine
  • 2,3,4,5-Tetrachloropyridine
  • 5-Chloro-2-methoxypyridine
  • 3-Chloropyridine 1-oxide
  • dichloroethane
  • (3,5,6-TRICHLORO-PYRIDIN-2-YL)-HYDRAZINE
  • 2,3,5-trichloro-4-hydrazino-pyridine
  • 5-chloro-2-pyridol
  • phosgene
  • 5-chloro-1-methylpyridin-2-one

DownStream

  • N-(5-chloropyridin-2-yl)-N'-phenylurea
  • 6-chloro-2-(4-chlorophenyl)-2H-pyrano[2,3-b]pyridine
  • 2,5-Dichloro-4-pyridinamine
  • 2-Bromo-5-chloropyridine
  • 5-chloropyridine-2-thiol
  • 2,5-Pyridinedicarboxylicacid, 2,5-diethyl ester
  • ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE
  • 2-Chloropyridine-5-boronic acid Pinacol ester
  • 2-Chloro-5-pyridineboronic acid
  • 2,5-Dichloro-3-iodopyridine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Coupling of heteroaryl chlorides with arylboronic acids in the presence of [1, 4-bis-(diphenylphosphine) butane] palladium (II) dichloride. Mitchell MB and Wallbank PJ.

Tetrahedron Lett. 32(20) , 2273-76, (1991)

Synthesis of novel halopyridinylboronic acids and esters. Part 1: 6-Halopyridin-3-yl-boronic acids and esters. Bouillon A, et al.

Tetrahedron 58(14) , 2885-90, (2002)


More Articles

Related Compounds

  • 2,5-DICHLOROPYRIDINE
  • 2,5-dichloropyridine-1-oxide
  • 4-Bromo-2,5-dichloropyridine
  • 4-Cyano-2,5-dichloropyridine
  • 3-Cyano-2,5-dichloropyridine
  • 3-nitro-2,5-dichloropyridine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 6-(2-Amino-1,3-thiazol-4-yl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • N-(3-Aminophenyl)-4-(sec-butoxy)benzamide