acetaminophen glucuronide

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Names

[ CAS No. ]:
16110-10-4

[ Name ]:
acetaminophen glucuronide

[Synonym ]:
Acetaminophen D-glucuronide
[14C]-Acetaminophen glucuronide
paracetamol glucuronide
acetaminophen glucuronide
acetaminophen O-beta-D-glucosiduronic acid
4-glucuronosido-acetanilide

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
697.4ºC at 760mmHg

[ Molecular Formula ]:
C14H14D3NO8

[ Molecular Weight ]:
330.30500

[ Flash Point ]:
375.6ºC

[ Exact Mass ]:
330.11400

[ PSA ]:
145.55000

[ Vapour Pressure ]:
2.03E-20mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Acetamidophenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester
  • 2,3,4-Tri-O-acetyl-α-D-glucuronic Acid Methyl Ester
  • 3,4,6-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANOSE 1,2-(METHYL ORTHOACETATE)
  • (2S,3S,4S,5R,6S)-6-(4-aminophenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
  • Ethanoic anhydride
  • 4-Acetamidophenol
  • (2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic
  • UDPGA TRIAMMONIUM SALT

DownStream

  • 4-Acetamidophenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester

Articles

Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.

Clin. Exp. Pharmacol. Physiol. 36(1) , 35-42, (2009)

1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over ...

Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.

Bioanalysis 4(12) , 1429-43, (2012)

In support of a pilot clinical trial using acetaminophen as the model compound to assess dried blood spot (DBS) sampling as the method for clinical pharmacokinetic sample collection, a novel sensitive...

Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.

Int. J. Clin. Pharmacol. Ther. 45(9) , 496-503, (2007)

Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations, a small fraction of the drug undergoes o...


More Articles

Related Compounds

  • acetaminophen glucuronide sodium salt
  • Acetaminophen Glucuronide Methyl Ester
  • 3-METHYL-THIOACETAMINOPHEN GLUCURONIDE
  • Acetaminophen dimer-d6
  • (4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine,N-(4-hydroxyphenyl)acetamide,phosphoric acid,hydrochloride
  • Acetaminophen Glutathione-¹³C2,¹⁵N Disodium Salt
  • 2-Amino-6-methylpyridine-4-carbonitrile
  • 4-Amino-2-methylenebutan-1-ol
  • (2,2-Dimethylpropyl)(1-phenylpropyl)amine
  • (2S)-2-amino-2-(2,3-dihydro-1H-inden-5-yl)ethan-1-ol
  • N-(2,2-dimethylpropyl)cyclobutanamine
  • 6-Fluoro-3-methoxypyrazin-2-amine
  • 2-Chloro-3-phenyl-1,6-naphthyridine-5-carbaldehyde
  • Rel-(1R,6R)-6-methylcyclohex-3-en-1-amine
  • Cyclopropanepropanamine, beta,beta-dimethyl-
  • R-2-Amino-3-cyclopropylmethylsulfanyl-propan-1-ol
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