2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine

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Names

[ CAS No. ]:
161696-76-0

[ Name ]:
2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine

[Synonym ]:
Desmethylolanzapine dihydrochloride
2-methyl-4-piperazin-1-yl-5H-thieno[3,2-c][1,5]benzodiazepine

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
489.2ºC at 760 mmHg

[ Melting Point ]:
144.5ºC

[ Molecular Formula ]:
C16H18N4S

[ Molecular Weight ]:
298.41

[ Flash Point ]:
249.7ºC

[ Exact Mass ]:
298.12500

[ PSA ]:
67.90000

[ LogP ]:
2.93730

[ Vapour Pressure ]:
1.02E-09mmHg at 25°C

[ Index of Refraction ]:
1.742

[ Storage condition ]:
-20°C Freezer

MSDS

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Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-26-36/37

[ RIDADR ]:
UN 1648 3 / PGII

[ HS Code ]:
2934999090

Synthetic Route

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Precursor & DownStream

Precursor

  • ethyl 4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine-1-carboxylate
  • Piperazine
  • 4-AMINO-2-METHYL-10H-THIENO(2,3-B)(1,5)-BENZODIAZEPINE
  • 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
  • 2-Amino-5-methylthiophene-3-carbonitrile

DownStream

  • Olanzapine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%