Rasagiline mesylate

Suppliers

Names

[ Name ]:
Rasagiline mesylate

[Synonym ]:
acide méthanesulfonique - (1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-indén-1-amine (1:1)
Methansulfonsäure--(1R)-N-prop-2-in-1-yl-2,3-dihydro-1H-inden-1-amin(1:1)
methanesulfonic acid,(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
(1R)-N-(Prop-2-yn-1-yl)indan-1-amine methanesulfonate (1:1)
(1R)-N-(2-Propyn-1-yl)-1-indanamine methanesulfonate (1:1)
(1R)-N-prop-2-yn-1-yl-2,3-dihydro-1H-inden-1-amine methanesulfonate
Rasagiline mesylate
(R)-N-(Prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate
(1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate (1:1)
1H-Inden-1-amine, 2,3-dihydro-N-2-propyn-1-yl-, (1R)-, methanesulfonate (1:1)
1H-inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)-, methanesulfonate (1:1)
Rasagiline (mesylate)

Chemical & Physical Properties

[ Density]:
1.05 g/cm3

[ Boiling Point ]:
305.5ºC at 760 mmHg

[ Melting Point ]:
155-158°C

[ Molecular Formula ]:
C₁₃H₁₇NO₃S

[ Molecular Weight ]:
267.344

[ Flash Point ]:
146.8ºC

[ Exact Mass ]:
267.092926

[ PSA ]:
74.78000

[ LogP ]:
2.87240

[ Vapour Pressure ]:
0.000816mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methanesulfonic acid
Rasagiline
rasagiline hydrobromide
1-Indanone
(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate
(E)-2,3-dihydro-1H-inden-1-one oxime
1-Indanamine
N-(2-PROPYNYL)-2,3-DIHYDROINDEN-1-AMINE

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

Lancet 365(9463) , 947-54, (2005)

Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B) inhibitor activity, and is effective as monotherapy in early disease. This study in...

Rasagiline mesylate, a new MAO-B inhibitor for the treatment of Parkinson's disease: a double-blind study as adjunctive therapy to levodopa.

Clin. Neuropharmacol. 23(6) , 324-30, (2000)

Rasagiline mesylate (TVP-1012) is a potent, selective, non-reversible MAO-B inhibitor, without the tyramine-potentiating effect and with neuroprotective activities. The benefit of rasagiline as monoth...

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

Neuroreport 9(4) , 703-7, (1998)

Both deprenyl and rasagiline (R(+)-N-propargyl-1-aminoindane mesylate), at a concentration of 1-10 microM, increased survival in vitro of rat E14 mesencephalic dopaminergic neurons that had been prime...