3-Quinuclidinol

Names

[ CAS No. ]:
1619-34-7

[ Name ]:
3-Quinuclidinol

[Synonym ]:
Quinuclidine-3-ol
Quinuclidin-3-ol
MFCD00151326
UNII:974MVZ0WOK
3-Hydroxyquinuclidine
1-Azabicyclo[2.2.2]octan-3-ol
Quinuclidinol
1-Aza-bicyclo[2.2.2]octan-3-ol
QUINICLIDINE-3-OL
3-Quinuclidinol
3-Quinuclidinol dl-form
3-HYDROXYCHINUCLIDIN
1-Azabicyclo(2.2.2)octan-3-ol
Quinuclidinol-3
3(R)-hydroxy-1-azabicyclo[2.2.2]octane
(+)-1-azabicyclo[2.2.2]octan-3-ol
EINECS 216-578-4
Solifenacin Impurity 11

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
206.9±23.0 °C at 760 mmHg

[ Melting Point ]:
217-224 ºC

[ Molecular Formula ]:
C7H13NO

[ Molecular Weight ]:
127.184

[ Flash Point ]:
97.7±21.3 °C

[ Exact Mass ]:
127.099716

[ PSA ]:
23.47000

[ LogP ]:
-0.07

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.549

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VD6191700
CHEMICAL NAME :
3-Quinuclidinol
CAS REGISTRY NUMBER :
1619-34-7
BEILSTEIN REFERENCE NO. :
0104327
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H13-N-O
MOLECULAR WEIGHT :
127.21
WISWESSER LINE NOTATION :
T66 A B CNTJ AQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :
Rodent - hamster
DOSE/DURATION :
10 mg/kg
REFERENCE :
ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975

Safety Information

[ Hazard Codes ]:
F:Flammable;C:Corrosive;

[ Risk Phrases ]:
R11;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S16

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
VD6191700

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933392000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-QUINUCLIDINONE
  • 3-Quinuclidinone hydrochloride
  • Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate
  • 3-hydroxy-1-(4-nitrophenethyl)quinuclidin-1-ium

DownStream

  • 3-QUINUCLIDINONE
  • 1-azabicyclo[2.2.2]oct-2-ene
  • 3-Chloroquinuclidine hydrochloride
  • 3-Quinuclidinyl alpha-phenylcyclohexaneglycolate
  • Aceclidine
  • (1S)-(3S)-1-Azabicyclo[2.2.2]oct-3-yl 3,4-Dihydro-1-phenyl-2(1H)-isoquinoline carboxylate
  • solifenacin
  • (1R)-(3S)-1-Azabicyclo[2.2.2]oct-3-yl 3,4-Dihydro-1-phenyl-2(1H)-isoquinoline carboxylate
  • (1R)-(3R)-1-Azabicyclo[2.2.2]oct-3-yl 3,4-Dihydro-1-phenyl-2(1H)-isoquinoline carboxylate
  • 1-azabicyclo[2.2.2]octan-3-yl 2-(cyclopenten-1-yl)-2-hydroxy-2-phenylacetate

Customs

[ HS Code ]: 2933392000

[ Summary ]:
2933392000 quinuclidin-3-ol。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Related Compounds

  • 3-Quinuclidinol
  • dl-3-Quinuclidinol
  • 3-Quinuclidinol HCl
  • (R)-3-Quinuclidinol HCl
  • N-allyl-3-quinuclidinol
  • 3-Quinuclidinol benzoate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 2-Amino-2-[1-(2-methyl-1,3-thiazol-5-yl)cyclopropyl]acetic acid
  • 5-(3-bromo-2,2-dimethylpropyl)-1-(propan-2-yl)-1H-pyrazole
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine