Roflumilast

Suppliers

Names

[ Name ]:
Roflumilast

[Synonym ]:
Daxas
EINECS 223-583-8
3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
MFCD00938270
Roflumilast
3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE
Daliresp

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
430.6±45.0 °C at 760 mmHg

[ Melting Point ]:
158°C

[ Molecular Formula ]:
C₁₇H₁₄Cl₂F₂N₂O₃

[ Molecular Weight ]:
403.207

[ Flash Point ]:
214.2±28.7 °C

[ Exact Mass ]:
402.034943

[ PSA ]:
60.45000

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.604

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study.

BMC Clin. Pharmacol. 11 , 7, (2011)

Roflumilast is an oral, selective phosphodiesterase 4 inhibitor with anti-inflammatory effects in chronic obstructive pulmonary disease (COPD). The addition of roflumilast to long-acting bronchodilato...

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

PLoS ONE 6 , e20000, (2011)

Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced...

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.

Lancet 385(9971) , 857-66, (2015)

Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids and longacting β2 agonists i...

Roflumilast-d3
Roflumilast-d4
Roflumilast-im C
Roflumilast N-oxide
Roflumilast-d4 N-Oxide
Roflumilast Impurity 5
1,1-Dimethylethyl 4-[(6R)-5-(2-amino-4-pyridinyl)-4,5,6,7-tetrahydro-6-methylpyrazolo[1,5-a]pyrazin-3-yl]-1-piperidinecarboxylate
Ethyl 2-[(3,4-dimethoxyphenyl)methylene]-5-(4-fluorophenyl)-2,3-dihydro-3-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
2,3-Pyrrolidinedione, 4-[(2,3-dihydro-2-methyl-5-benzofuranyl)carbonyl]-5-[4-(dimethylamino)phenyl]-1-[3-(4-morpholinyl)propyl]-
2H-Isoindole-2-propanoic acid, 1,3-dihydro-6-methoxy-I+/--[(methoxycarbonyl)amino]-1-oxo-I+/--(2-phenylethynyl)-, methyl ester, (I+/-R)-
1,5,6,8-Tetrahydro-I,8-dioxo-I+/--[[(phenylmethoxy)carbonyl]amino]-1,5-methano-2H-pyrido[1,2-a][1,5]diazocine-3(4H)-pentanoic acid
3-[[6-O-(6-Deoxy-I(2)-L-mannofuranosyl)-I(2)-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
2-(4-Nitrophenyl)ethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
2-[2-[2,6-Diamino-3-[2-(4-methoxy-2-sulfophenyl)diazenyl]phenyl]diazenyl]-5-[[2-(sulfooxy)ethyl]sulfonyl]benzenesulfonic acid
(3aR,4S,6E,9R,10E,11aR)-4-(Acetyloxy)-3a,4,5,8,9,11a-hexahydro-9-hydroxy-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one
1H-Pyrrolo[4a(2),3a(2):1,4]cyclobuta[1,2-b]pyrrole-1-carboxylic acid, octahydro-5-oxo-, 1,1-dimethylethyl ester, (3aR,4aS,7aS)-rel-

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