Roflumilast

Suppliers

Names

[ Name ]:
Roflumilast

[Synonym ]:
Daxas
EINECS 223-583-8
3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
MFCD00938270
Roflumilast
3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE
Daliresp

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
430.6±45.0 °C at 760 mmHg

[ Melting Point ]:
158°C

[ Molecular Formula ]:
C₁₇H₁₄Cl₂F₂N₂O₃

[ Molecular Weight ]:
403.207

[ Flash Point ]:
214.2±28.7 °C

[ Exact Mass ]:
402.034943

[ PSA ]:
60.45000

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.604

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study.

BMC Clin. Pharmacol. 11 , 7, (2011)

Roflumilast is an oral, selective phosphodiesterase 4 inhibitor with anti-inflammatory effects in chronic obstructive pulmonary disease (COPD). The addition of roflumilast to long-acting bronchodilato...

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

PLoS ONE 6 , e20000, (2011)

Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced...

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.

Lancet 385(9971) , 857-66, (2015)

Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids and longacting β2 agonists i...

Roflumilast-d3
Roflumilast-d4
Roflumilast-im C
Roflumilast N-oxide
Roflumilast-d4 N-Oxide
Roflumilast Impurity 5
3-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-4,4-dimethylcyclohexan-1-ol
4-(3-Chloro-2-methylpropyl)-3-methoxy-1,2-thiazole
1-(tert-butyldimethylsilyl)-1H-indole-4-sulfonamide
1-[1-(azetidin-3-yl)-1H-pyrazol-5-yl]-3-(1-methoxypropan-2-yl)thiourea
rac-(3R,4R)-3-fluoro-4-methylpyrrolidine-3-carboxylic acid
Ethyl 2-methyl-2-[(2-phenoxyethyl)amino]propanoate
2-{[1-(azetidin-3-yl)-1H-pyrazol-5-yl]sulfamoyl}propanethioamide
4-amino-N-[1-(azetidin-3-yl)-1H-pyrazol-5-yl]hexanamide
methyl (3S)-3-amino-4-(4-cyanophenyl)butanoate
Ethyl 2-amino-6-fluoro-4-(pyridin-3-yl)benzoate

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