Roflumilast

Suppliers

Names

[ CAS No. ]:
162401-32-3

[ Name ]:
Roflumilast

[Synonym ]:
Daxas
EINECS 223-583-8
3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
MFCD00938270
Roflumilast
3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE
Daliresp

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
430.6±45.0 °C at 760 mmHg

[ Melting Point ]:
158°C

[ Molecular Formula ]:
C17H14Cl2F2N2O3

[ Molecular Weight ]:
403.207

[ Flash Point ]:
214.2±28.7 °C

[ Exact Mass ]:
402.034943

[ PSA ]:
60.45000

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.604

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study.

BMC Clin. Pharmacol. 11 , 7, (2011)

Roflumilast is an oral, selective phosphodiesterase 4 inhibitor with anti-inflammatory effects in chronic obstructive pulmonary disease (COPD). The addition of roflumilast to long-acting bronchodilato...

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

PLoS ONE 6 , e20000, (2011)

Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced...

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.

Lancet 385(9971) , 857-66, (2015)

Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids and longacting β2 agonists i...


More Articles


Related Compounds

  • Roflumilast-d3
  • Roflumilast-d4
  • Roflumilast-im C
  • Roflumilast N-oxide
  • Roflumilast-d4 N-Oxide
  • Roflumilast Impurity 5
  • 4-Azabicyclo[6.1.0]nonane-8-carboxylic acid
  • 3-{[(Tert-butoxy)carbonyl](pyridin-2-yl)amino}propanoic acid
  • 1-Chloro-4-methyl-2-(prop-2-yn-1-yl)benzene
  • tert-butyl N-{[2-(2-hydroxypropoxy)phenyl]methyl}carbamate
  • rac-(1R,6S,7S)-7-amino-2-oxabicyclo[4.2.0]octane-7-carboxylic acid
  • 2-Amino-3-(quinazolin-4-yl)propanoic acid dihydrochloride
  • rac-[(1R,3S)-3-(aminomethyl)-1-fluorocyclopentyl]methanamine
  • Tert-butyl 1-chloro-6-azaspiro[2.5]octane-1-carboxylate
  • rac-tert-butyl (7R,8S)-7,8-dihydroxy-5-azaspiro[3.4]octane-5-carboxylate
  • 2-tert-butyl-N-(2-oxobenzimidazol-5-yl)imidazo[1,2-b]pyridazine-6-carboxamide
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.