Temsirolimus (CCI-779)

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Names

[ CAS No. ]:
162635-04-3

[ Name ]:
Temsirolimus (CCI-779)

[Synonym ]:
CCL-779
TeMsiroliMus (~)
Torisel
Temsirolimus
[14C]-Temsirolimus
42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin
Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, (1R,2R,4S)-2-methoxy-4-[(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,26R,27R,34aS)-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontin-3-yl]propyl]cyclohexyl ester
Rapamycin (42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
TeMsiroliMus (Torisel)
Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate
rapaMycin 42-ester with 3-hydroxy-2-(hydroxyMethyl)-2-Methylpropionic acid
(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-Dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0] hexatriaconta-16,24,26,28-tetraen-12-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
NSC 683864

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1048.4±75.0 °C at 760 mmHg

[ Melting Point ]:
99-101ºC

[ Molecular Formula ]:
C56H87NO16

[ Molecular Weight ]:
1030.287

[ Flash Point ]:
587.8±37.1 °C

[ Exact Mass ]:
1029.602539

[ PSA ]:
241.96000

[ LogP ]:
2.96

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
Soluble in chloroform, methanol.

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VE6257000

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Temsirolimus Acetonide
  • temisirolimus methyl acetal

DownStream

Articles

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.

EMBO J. 34 , 1214-30, (2015)

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, in...

Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.

PLoS ONE 10 , e0131241, (2015)

Blocking the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of HER2-positive breast carcinoma cells. The hypothesis is that blocking FASN, in combination with anti-HER2 signaling agents, would b...

Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models.

Gynecol. Oncol. 138 , 165-73, (2015)

Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment options are limited for advanced and recurrent disease. Therefore, new treatment options are necessar...


More Articles

Related Compounds

  • Temsirolimus Acetonide
  • Temsirolimus-d7
  • disodium,[5-[5-hydroxy-4-oxo-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-2-yl]-2-methoxyphenyl] phosphate
  • A 779
  • TAK-779
  • VINYLCYCLOHEXANE
  • Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}-3-(3-methylthiophen-2-yl)propanoate
  • 2-Tert-butyl 5-chloromethyl 2-azabicyclo[2.1.0]pentane-2,5-dicarboxylate
  • 2-tert-butyl 4-chloromethyl 2,3-dihydro-1H-isoindole-2,4-dicarboxylate
  • 2-{[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl}acetamide
  • 2-cyano-N-[4-(4-fluorophenyl)piperidin-3-yl]acetamide
  • 2-(dimethylamino)-N-[4-(4-fluorophenyl)piperidin-3-yl]acetamide
  • 1-[3-Amino-4-(4-fluorophenyl)piperidin-1-yl]-2-(dimethylamino)ethan-1-one
  • 2-methyl-N-(4-phenylpiperidin-3-yl)prop-2-enamide
  • 1-(3-Amino-4-phenylpiperidin-1-yl)-2-methylprop-2-en-1-one
  • 2-methoxy-N-(4-phenylpiperidin-3-yl)acetamide