2-CL-IB-MECA

Suppliers

Names

[ CAS No. ]:
163042-96-4

[ Name ]:
2-CL-IB-MECA

[Synonym ]:
CF102
CI-IB-MECA
2-Cl-IB-Meca
Cl-IB-MECA
Namodenoson
2-chloro-IB-MECA
(2S,3S,4R,5R)-5-{2-Chloro-6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-3,4-dihydroxy-N-methyltetrahydro-2-furancarboxamide (non-preferred name)
UNII:Z07JR07J6C
CF-102
CF-102(2-Cl-IB-MECA)

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Melting Point ]:
209 °C

[ Molecular Formula ]:
C18H18ClIN6O4

[ Molecular Weight ]:
544.731

[ Exact Mass ]:
544.012268

[ PSA ]:
134.42000

[ LogP ]:
3.14

[ Index of Refraction ]:
1.814

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzylamine, m-iodo-, hydrochloride
  • 2,6-Dichloropurine
  • 2-chloro-N-6-(3-iodobenzyl)adenine
  • IB-MECA

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma.

Cancer Chemother. Pharmacol. 74(4) , 847-60, (2014)

Metastatic melanoma is considered one of the most aggressive malignant tumours, representing the deadliest form of skin cancer. Melanoma progression is associated with the abrogation of normal control...

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.

J. Neurosci. 17 , 607-614, (1997)

The adenosine A3 receptor is expressed in brain, but the consequences of activation of this receptor on electrophysiological activity are unknown. We have characterized the actions of a selective aden...

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.

Cell Death Dis. 5 , e1539, (2014)

Therapies that target the signal transduction and biological characteristics of cancer stem cells (CSCs) are innovative strategies that are used in combination with conventional chemotherapy and radio...


More Articles

Related Compounds

  • 2-Cl-IB-MECA
  • 2-Cl-C6H4OBCl2
  • (2-Cl-4-NO2C6H3NH3)Cl
  • licopyranocoumarin
  • NaSC6H4-2-Cl
  • Fmoc-MeHph(2-Cl)-OH
  • 2,3-Dihydro-3-methylene-1H-pyrido[3,2,1-kl]phenothiazine
  • 2-(4-Methoxy-2,6-dimethylphenyl)acetic acid
  • 6-(2-Methoxyethoxy)-3-pyridazinamine
  • (2R)-({[(3S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl}amino)(phenyl)ethanoic acid
  • 1-{[(3S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl}piperidine-4-carboxylic acid
  • 6-Benzyl-2-(3-phenoxybenzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 3,5-Dibromo-4-fluorobenzotrifluoride
  • (2S)-N-(6-aminohexyl)-1-tridecanoylpyrrolidine-2-carboxamide
  • 1-Propylcyclopropane-1-carboxylic acid
  • 2-Cyclopropylprop-2-enenitrile
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