Piperazine,1-methyl-4-nitroso-

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Names

[ CAS No. ]:
16339-07-4

[ Name ]:
Piperazine,1-methyl-4-nitroso-

[Synonym ]:
N-Nitrosomethylpiperazine
N-Nitroso-N'-methylpiperazine
1-Nitroso-4-methylpiperazine
N-Nitroso-N'-methylpiperazin
N-Methyl-npz
Methylpiperazinenitrosamine
N-Methylnitrosopiperazine
1-methyl-4-nitroso-piperazine
PIPERAZINE,1-METHYL-4-NITROSO
Methylnitrosopiperidine

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
236.9ºC at 760mmHg

[ Molecular Formula ]:
C5H11N3O

[ Molecular Weight ]:
129.16000

[ Flash Point ]:
97.1ºC

[ Exact Mass ]:
129.09000

[ PSA ]:
35.91000

[ Vapour Pressure ]:
0.0463mmHg at 25°C

[ Index of Refraction ]:
1.561

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM1780000
CHEMICAL NAME :
Piperazine, 1-methyl-4-nitroso-
CAS REGISTRY NUMBER :
16339-07-4
BEILSTEIN REFERENCE NO. :
0117135
LAST UPDATED :
199612
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C5-H11-N3-O
MOLECULAR WEIGHT :
129.19
WISWESSER LINE NOTATION :
T6N DNTJ ANO D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/59W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20800 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11440 mg/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,1044,1977

Safety Information

[ HS Code ]:
2933599090

Precursor & DownStream

Precursor

  • methylpiperazine
  • Nitrous acid, propylester
  • Butyl nitrite
  • 2-hydroxyethyl nitrite

DownStream

  • methylpiperazine
  • 4-Methyl-1-piperazinamine
  • N,N'-Dinitrosopiperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Piperazine,1-methyl-4-[[3-methyl-4-(1-methylethyl)-5-oxo-2(5H)-isoxazolyl]carbonyl]- (9CI)
  • Piperazine, 1-methyl-4-[(methylamino)acetyl]- (9CI)
  • Piperazine, 1-methyl-4-[2-(trimethylsilyl)ethyl]- (9CI)
  • Piperazine, 1-methyl-4-(2-pyridinyl)- (9CI)
  • Piperazine,1-methyl-4-(2-methylphenyl)-
  • Piperazine, 1-methyl-4-(2-methyl-1,3-pentadienyl)-, (Z,E)- (9CI)
  • Chromate(1-), diaqua[4-[4,5-dihydro-4-[[2-(hydroxy-kappaO)-5-nitrophenyl]azo-kappaN1]-3-methyl-5-(oxo-kappaO)-1H-pyrazol-1-yl]benzenesulfonato(3-)]hydroxy-, sodium
  • 4-(2-methylpropanamido)-3-(pyridin-2-yl)-N-{[2-(trifluoromethyl)phenyl]methyl}-1,2-thiazole-5-carboxamide
  • FP-Biotin-d4
  • (3r)-1,7-Diphenyl-(4e,6e)-4,6-heptadien-3-ol
  • Boceprevir metabolite SCH 564649
  • (I+/-S)-4-Hydroxy-I+/--[(3E)-4-phenyl-3-buten-1-yl]benzenepropanol
  • (-)-(3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol
  • 4,6-Dimethyl-2-pyrimidinethiol hydrochloride hydrate
  • 2-(2-(tert-butyl)-6-chloro-3-oxo-2,3-dihydro-1H-indazol-1-yl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
  • 1'-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3H-spiro[isobenzofuran-1,4'-piperidine]
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