(R)-Boc-Nipecotic acid

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Names

[ Name ]:
(R)-Boc-Nipecotic acid

[Synonym ]:
(R)-N-BOC-piperidine-3-carboxylic acid
1-Boc-D-nipecotic acid
(R)-Boc-Nip-OH
(3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid
MFCD02179173
(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid
N-Boc-R-3-carboxylic acid piperidine
(R)-1-Boc-nipecotic Acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
353.2±35.0 °C at 760 mmHg

[ Melting Point ]:
165 °C(dec.)

[ Molecular Formula ]:
C₁₁H₁₉NO₄

[ Molecular Weight ]:
229.27

[ Flash Point ]:
167.4±25.9 °C

[ Exact Mass ]:
229.131409

[ PSA ]:
66.84000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.496

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

MK-8776(SCH 900776)
(S)-tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
VTP 27999 trifluoroacetate
1-Piperidinecarboxylic acid, 3-[(MethoxyMethylamino)carbonyl]-, 1,1-dimethylethyl ester, (3R)-
1-(tert-Butyl) 3-methyl (R)-piperidine-1,3-dicarboxylate
tert-butyl (3R)-3-[(R)-(3-chlorophenyl)-[2-(methoxycarbonylamino)ethoxy]methyl]piperidine-1-carboxylate

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A.

PLoS ONE 10 , e0136242, (2015)

CCG-1423 suppresses several pathological processes including cancer cell migration, tissue fibrosis, and the development of atherosclerotic lesions. These suppressions are caused by inhibition of myoc...