Dutasteride

Suppliers

Names

[ Name ]:
Dutasteride

[Synonym ]:
(5a,17b)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
(5α,17β)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Avodart
Duagen
α,α,α,α',α',α'-Hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide
Dutasteride
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
a,a,a,a',a',a'-Hexafluoro-3-oxo-4-aza-5a-androst-1-ene-17b-carboxy-2',5'-xylidide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
620.3±55.0 °C at 760 mmHg

[ Melting Point ]:
242-250ºC

[ Molecular Formula ]:
C₂₇H₃₀F₆N₂O₂

[ Molecular Weight ]:
528.530

[ Flash Point ]:
329.0±31.5 °C

[ Exact Mass ]:
528.221130

[ PSA ]:
58.20000

[ LogP ]:
5.61

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
DMSO: soluble2mg/mL, clear

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro

J. Steroid Biochem. Mol. Biol. 144 Pt B , 436-44, (2014)

• Dutasteride and abiraterone were evaluated for inhibition of steroidogenesis. • Bypass mechanisms arise in the presence of abiraterone to form DHT. • Dutasteride inhibits T and DHT effectively in vi...

Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction.

Arch. Pharm. Res. 37(12) , 1570-7, (2014)

The objective of this study was to prepare and characterize dutasteride (a hydrophobic model drug) microcapsules using ethyl cellulose as a capsule shell polymer with different drug/polymer ratios of ...

Long term effectiveness on prescribing of two multifaceted educational interventions: results of two large scale randomized cluster trials.

PLoS ONE 9(10) , e109915, (2014)

Information on benefits and risks of drugs is a key element affecting doctors' prescribing decisions. Outreach visits promoting independent information have proved moderately effective in changing pre...