Podophyllotoxin β-D-glucoside

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Names

[ CAS No. ]:
16481-54-2

[ Name ]:
Podophyllotoxin β-D-glucoside

[Synonym ]:
Podophyllotoxin-7-O-glucoside
Podophyllotoxin 4-O-glucoside
(5R,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl β-D-glucopyranoside
Podophyllotoxin glucoside
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-(β-D-glucopyranosyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
Podophyllotoxin, 3-β-D-glucopyranoside
Podophyllotoxin-4-O-glucoside
Podophyllotoxin-β-D-glucoside

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
781.3±60.0 °C at 760 mmHg

[ Melting Point ]:
152-154℃

[ Molecular Formula ]:
C28H32O13

[ Molecular Weight ]:
576.546

[ Flash Point ]:
258.2±26.4 °C

[ Exact Mass ]:
576.184265

[ PSA ]:
171.83000

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.660

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP9002050
CHEMICAL NAME :
Podophyllotoxin, 4,6-O-benzylidene-beta-D-glucopyranoside
CAS REGISTRY NUMBER :
16481-54-2
LAST UPDATED :
199012
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H32-O13
MOLECULAR WEIGHT :
576.60
WISWESSER LINE NOTATION :
T E5 C665 FVO NO PO OHTT&&J DR CO1 DO1 EO1& JO- HT66 BO DO GOTJ CR& IQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
30 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2998,1977

Precursor & DownStream

Precursor

  • diazomethane
  • Uridine diphosphate glucose
  • Podophyllotoxin

DownStream

  • Podophyllotoxin

Related Compounds

  • DIBOA β-D-glucoside
  • podorhizol β-D-glucoside
  • Retigabine N-β-D-Glucoside
  • 4-methylumbelliferyl β-D-glucoside
  • pyridoxine 3-β-D-glucoside
  • Magnolioside
  • 2-((2-(1H-indol-3-yl)-2-oxoethyl)thio)-N,3-bis(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide
  • N-(2-fluorobenzyl)-2-[6-oxo-3-(4-phenylpiperazin-1-yl)pyridazin-1(6H)-yl]acetamide
  • 3-Chloro-6-(2-nitrophenyl)pyridazine
  • 2-(3-(3-chlorobenzoyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl)-N-cyclohexylacetamide
  • N-[4-({4-[2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl]piperidin-1-yl}sulfonyl)phenyl]acetamide
  • N-(3-chlorobenzyl)-2-[6-oxo-3-(4-phenylpiperazin-1-yl)pyridazin-1(6H)-yl]acetamide
  • 2-((2-(1H-indol-3-yl)-2-oxoethyl)thio)-N-isobutyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide
  • N-cyclopentyl-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-4-oxo-3-[(oxolan-2-yl)methyl]-3,4-dihydroquinazoline-7-carboxamide
  • N-cyclopentyl-2-{[2-(2,5-dimethylphenyl)-2-oxoethyl]sulfanyl}-4-oxo-3-[(oxolan-2-yl)methyl]-3,4-dihydroquinazoline-7-carboxamide
  • 1-(2-Aminoethyl)-3-(2,6-dichlorophenyl)-2-methylthiopseudourea
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