Hydrazinecarboxaldehyde,2-ethylidene-1-methyl-

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Names

[ CAS No. ]:
16568-02-8

[ Name ]:
Hydrazinecarboxaldehyde,2-ethylidene-1-methyl-

[Synonym ]:
GYROMITRIN
Formic acid,2-ethylidene-1-methylhydrazide
2-Aethyliden-1-formyl-1-methylhydrazin
Acetaldehyde,N-formyl-N-methylhydrazone
Formic acid,ethylidenemethylhydrazide
Hydrazinecarboxaldehyde,ethylidenemethyl
Acetaldehyde methylformylhydrazone
Acetaldehyde N-methylformylhydrazone
Acetaldehyde N-methyl-N-formylhydrazone
N-[(E)-ethylideneamino]-N-methylformamide

Chemical & Physical Properties

[ Density]:
0.93g/cm3

[ Boiling Point ]:
135.8ºC at 760mmHg

[ Melting Point ]:
19.5ºC (VACUUM)

[ Molecular Formula ]:
C4H8N2O

[ Molecular Weight ]:
100.11900

[ Flash Point ]:
36ºC

[ Exact Mass ]:
100.06400

[ PSA ]:
32.67000

[ LogP ]:
0.71620

[ Vapour Pressure ]:
7.587mmHg at 25°C

[ Index of Refraction ]:
1.442

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ8500000
CHEMICAL NAME :
Formic acid, ethylidenemethylhydrazide
CAS REGISTRY NUMBER :
16568-02-8
LAST UPDATED :
199612
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C4-H8-N2-O
MOLECULAR WEIGHT :
100.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern, Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern, Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 15,575,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
344 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,167,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 62,395,1975 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5200 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 39,884,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 28,559,1981 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,391,1987 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,163,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr., Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7, Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds

  • (E)-2-ethylidene-1-methyl-4-phenyl-1,2-dihydroquinoline
  • 2-ethylidene-1-methyl-1-(2-methylprop-2-enyl)cyclopentane
  • Hydrazinecarboxaldehyde,2-(1,2,5,6-tetrahydro-1-methyl-5-nitro-2,6-dioxo-4-pyrimidinyl)- (9CI)
  • Pyridine, 2-ethylidene-1,2-dihydro-1-methyl- (9CI)
  • 2-(3-Ethylidene-1-methyl-4-piperidinyl)-2-(3-methyl-1H-indol-2-yl)-1,3-propanediol
  • Pyrrolidine, 2-ethylidene-1,5-dimethyl-3,3-diphenyl-
  • 1-(3-Phenylprop-2-yn-1-yl)cyclopropane-1-sulfonyl chloride
  • N-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Quinolinamine
  • Methyl 4-bromo-5-methoxy-3-methyl-benzofuran-2-carboxylate
  • 3-Amino-4-propylcyclohexan-1-ol
  • (5-Ethynyl-3-methoxypyridin-2-yl)methanamine
  • 1-[5-Chloro-6-(propan-2-yloxy)pyridin-3-yl]-2,2-difluoroethan-1-one
  • 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-amine
  • 4-ethyl-3-(1-methyl-1H-pyrazol-3-yl)cyclohexan-1-one
  • 2-Methoxy-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine
  • 4-[1-(2,6-Difluorophenyl)ethyl]piperidine