19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a
Suppliers
Names
[ CAS No. ]:
16623-56-6
[ Name ]:
19H-2,3,7-[1,3]Butadien[1]yl[4]ylidene-9,12-etheno-14,18-metheno-4H-pyrido[2,3,4-tu]-1,13,6-benzodioxaazacyclodocosine,5,6,7,8,19a,20,21,22-octahydro-15,24,25,31,32-pentamethoxy-6,20-dimethyl-,(7S,19a
[Synonym ]:
O-methyl-thalfoetidine
O-Methylthalfetidine
6,6',7,7',12-Pentamethoxy-2,2'-dimethylthalidasan
Thalidasin
O-Methylthalfoetidin
O-methyl-thalrugosidine
Thalidusine,(S,S)
6,7,12,6',7'-pentamethoxy-2,2'-dimethyl-thalidasane
Chemical & Physical Properties
[ Density]:
1.175g/cm3
[ Boiling Point ]:
739.9ºC at 760mmHg
[ Molecular Formula ]:
C39H44N2O7
[ Molecular Weight ]:
652.77600
[ Flash Point ]:
181.1ºC
[ Exact Mass ]:
652.31500
[ PSA ]:
71.09000
[ LogP ]:
7.04680
[ Vapour Pressure ]:
9.29E-22mmHg at 25°C
[ Index of Refraction ]:
1.58
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XG2005000
- CHEMICAL NAME :
- Thalidasine
- CAS REGISTRY NUMBER :
- 16623-56-6
- LAST UPDATED :
- 199412
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C39-H44-N2-O7
- MOLECULAR WEIGHT :
- 652.85
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 520 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(7),46,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2100 mg/kg/7D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Related to Chronic Data - death
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 11,217,1980