trans-4-(Trifluoromethyl)cinnamic acid

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Names

[ CAS No. ]:
16642-92-5

[ Name ]:
trans-4-(Trifluoromethyl)cinnamic acid

[Synonym ]:
PTF-CNA
QV1U1R DXFFF &&trans or E Form
4-Trifluoromethylcinnamic
trans-4-(Trifluoromethyl)cinnamic Acid
2-Propenoic acid, 3-[4-(trifluoromethyl)phenyl]-, (2E)-
(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propenoic acid
(2E)-3-[4-(trifluoromethyl)phenyl]acrylic acid
4-(Trifluoromethyl)cinnamic Acid
MFCD00002696
RARECHEM BK HW 0019

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
279.2±35.0 °C at 760 mmHg

[ Melting Point ]:
231-233 °C(lit.)

[ Molecular Formula ]:
C10H7F3O2

[ Molecular Weight ]:
216.157

[ Flash Point ]:
122.6±25.9 °C

[ Exact Mass ]:
216.039810

[ PSA ]:
37.30000

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.526

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Precursor & DownStream

Precursor

DownStream

  • 7-(trifluoromethyl)-2H-isoquinolin-1-one
  • 4-(Trifluoromethyl)hydrocinnamic acid
  • 3-[4-(Trifluoromethyl)phenyl]-1-propanamine
  • 3-[4-(trifluoromethyl)phenyl]prop-2-enoyl chloride
  • BENZENEPROPANOIC ACID, 4-(TRIFLUOROMETHYL)-, ETHYL ESTER

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.

Drug Metab. Dispos. 37(10) , 2061-8, (2009)

Leflunomide is a disease-modifying antirheumatic drug used for the treatment of rheumatoid arthritis (RA). Cytochromes P450, mainly CYP1A2 and CYP2C19, may be involved in the transformation of lefluno...


More Articles

Related Compounds

  • trans-4-(trifluoromethyl)cinnamic acid n-butyl ester
  • 3-Chloro-4-(trifluoromethyl)cinnamic acid
  • 2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID
  • trans-4-(trifluoromethyl)cyclohexanecarboxylic acid
  • trans-4-Hydroxycinnamic acid
  • Trans-(4-(trifluoromethyl)cyclohexyl)methanol
  • methyl N-{[3-(2-fluoro-4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl]acetyl}-beta-alaninate
  • 4-amino-1-methyl-6-(methylamino)-2(1H)-pyrimidinone
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine