4-(Chloromethyl)biphenyl

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Names

[ CAS No. ]:
1667-11-4

[ Name ]:
4-(Chloromethyl)biphenyl

[Synonym ]:
4-(Chloromethyl)-1,1'-biphenyl
4-(Chloromethyl)biphenyl
1-(chloromethyl)-4-phenylbenzene
1,1'-Biphenyl, 4-(chloromethyl)-
EINECS 216-786-5
Biphenyl, 4- (chloromethyl)-
MFCD00000917

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
322.4±21.0 °C at 760 mmHg

[ Melting Point ]:
70-73 °C(lit.)

[ Molecular Formula ]:
C13H11Cl

[ Molecular Weight ]:
202.679

[ Flash Point ]:
143.2±14.7 °C

[ Exact Mass ]:
202.054932

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.579

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV2087000
CHEMICAL NAME :
Biphenyl, 4-(chloromethyl)-
CAS REGISTRY NUMBER :
1667-11-4
BEILSTEIN REFERENCE NO. :
1863327
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C13-H11-Cl
MOLECULAR WEIGHT :
202.69
WISWESSER LINE NOTATION :
G1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
250 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2500 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
2500 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 2,33,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DV2087000

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Biphenylylmethanol
  • 2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one
  • Felbinac
  • Formaldehyde
  • Biphenyl
  • 4-Phenyltoluene
  • 4-Biphenylmagnesium bromide solution
  • Hydrochloric acid

DownStream

  • 4-Biphenylylmethanol
  • 3-(4-Biphenylyl)propanoic acid
  • 4-Biphenylcarbaldehyde
  • 4-CYANOMETHYLBIPHENYL
  • DL-3-(4-BIPHENYL)ALANINE HYDROCHLORIDE
  • Felbinac
  • 4-phenylcinnamic acid
  • 1-(diethoxyphosphorylmethyl)-4-phenylbenzene
  • felbinacethyl

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981.

Mutat. Res. 119(2) , 121-33, (1983)

4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethyl-biphenyl (4HMB) were tested for biological activity in the following assays: (i) the Salmonella/microsome assay; (ii) a bacteria...

The use of cultured mammalian cells the UKEMS collaborative genotoxicity trial (1981).

Mutat. Res. 100(1-4) , 271-6, (1982)

The effects of 4CMB, 4HMB and BC in the micronucleus test.

Mutat. Res. 100(1-4) , 353-6, (1982)


More Articles

Related Compounds

  • 4-CHLOROMETHYLBIPHENYL
  • 4-(4-chlorophenyl)benzyl chloride
  • 4-chlorooxolan-3-ol,formic acid
  • 4-Amino-1,2-dithiolane-4-carboxylic acid
  • 4-Amino-2-chloro-5-(1H-tetrazol-5-yl)benzenesulfonamide
  • 4-(4-Chlorophenyl)-4-Bromopiperide
  • (4-acetyl-3,5-diacetyloxyphenyl) acetate
  • 1-[4-(aminomethyl)phenyl]-N-cyclopropylmethanesulfonamide
  • (Pentan-3-yl)({[3-(trifluoromethyl)phenyl]methyl})amine
  • 4-bromo-N-tert-butyl-3-fluorobenzamide
  • 4-Chloro-N-(2-cyclopentyl-1-methylethyl)butanamide
  • N-(3-aminopropyl)-N'-(3-azidopropyl)butane-1,4-diamine
  • 5-(3,4-difluorophenyl)-3-[(2,5-dimethylphenyl)methyl]-3a,6a-dihydropyrrolo[3,4-d]triazole-4,6-dione
  • 2-Chloro-N-[3-(phenylmethoxy)phenyl]-4-pyrimidinamine
  • 2-Bromo-5-nonylpyridine
  • 5-(((4-Bromo-5-(dimethylamino)furan-2-yl)methylene)amino)-2-chlorobenzoic acid
  • Tert-butyl 3-methylimidazolidine-1-carboxylate