Doxepin

Suppliers

Names

[ Name ]:
Doxepin

[Synonym ]:
Quitaxon
Aponal
P-3693A
Doxepine
Curatin
Docepin
Doxepin hydrochloride,11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepinhydrochloride

Chemical & Physical Properties

[ Density]:
1.122 g/cm3

[ Boiling Point ]:
413.3ºC at 760 mmHg

[ Melting Point ]:
187-189ºC

[ Molecular Formula ]:
C₁₉H₂₁NO

[ Molecular Weight ]:
279.37600

[ Flash Point ]:
121.3ºC

[ Exact Mass ]:
279.16200

[ PSA ]:
12.47000

[ LogP ]:
3.96240

[ Vapour Pressure ]:
4.87E-07mmHg at 25°C

[ Index of Refraction ]:
1.5000 (estimate)

[ Storage condition ]:
Store at RT

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ4300000

CHEMICAL NAME :: Dibenz(b,e)oxepin-delta(sup 11(6H)),gamma-propylamine, N,N-dimethyl-

CAS REGISTRY NUMBER :: 1668-19-5

LAST UPDATED :: 199107

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H21-N-O

MOLECULAR WEIGHT :: 279.41

WISWESSER LINE NOTATION :: T C676 BY IO JHJ BU3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - bronchiectasis

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 10,327,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,863,1965

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
36/37/39-45

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Dimethylamine
Doxepin N-Oxide
Doxepin hydrochloride

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Doxepin
Doxepin-d3
Nordoxepin
doxepin HCl
doxepin HCl
DOXEPIN HCL
1-[1-(1,3-Benzothiazol-2-yl)cyclopropyl]methanamine dihydrochloride
1-Bromo-3-cyclopropyl-5,7-dimethyl-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one
Ethyl 4-(2-bromophenyl)-1-methylpyrrolidine-3-carboxylate
Ethyl 4-[4-(difluoromethoxy)phenyl]-1-methylpyrrolidine-3-carboxylate
3-Bromo-2-cyano-6-methylbenzenesulfonyl chloride
6-Azaspiro[3.5]nonan-1-one
Ethyl 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpyrrolidine-3-carboxylate
Ethyl 4-(2-fluorophenyl)-1-methylpyrrolidine-3-carboxylate
5-(indoline-1-carbonyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4(7H)-one
Ethyl 1-methyl-4-[4-(methylsulfanyl)phenyl]pyrrolidine-3-carboxylate

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