(9S)-6'-methoxycinchonan-9-ol monohydrochloride

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Names

[ CAS No. ]:
1668-99-1

[ Name ]:
(9S)-6'-methoxycinchonan-9-ol monohydrochloride

[Synonym ]:
Quinidine,monohydrochloride
EINECS 216-792-8
Chinidin hydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
495.9ºC at 760mmHg

[ Molecular Formula ]:
C20H25ClN2O2

[ Molecular Weight ]:
360.87800

[ Flash Point ]:
253.7ºC

[ Exact Mass ]:
360.16000

[ PSA ]:
45.59000

[ LogP ]:
3.91310

[ Vapour Pressure ]:
1.19E-10mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA5750000
CHEMICAL NAME :
Quinidine, monohydrochloride
CAS REGISTRY NUMBER :
1668-99-1
LAST UPDATED :
199506
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C20-H24-N2-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
263 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,203,1995

Related Compounds

  • (9S)-6'-Methoxycinchonan-9-ol sulfate hydrate (2:1:2)
  • (9S)-6'-Methoxycinchonan-9-ol sulfate (2:1)
  • (9S)-6'-methoxycinchonan-9-ol monohydrobromide
  • (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol,sulfuric acid,tetrahydrate
  • (S)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol,(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
  • quinidine polygalacturonate
  • 5-Chloro-7-(difluoromethyl)-2-(2-methylbutan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
  • (2-(Hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)methyl acetate
  • 5',5''''-((2,5-Bis(trifluoromethyl)-1,4-phenylene)bis(ethyne-2,1-diyl))bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid))
  • N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((cyclooct-2-en-1-yloxy)carbonyl)lysine
  • (11bS)-2,6-Bis(3,5-bis(benzyloxy)phenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-olate 4-oxide
  • 2,2-Dimethyl-1-(3-(naphthalen-1-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrol-1-yl)propan-1-one
  • 2,4-Dichloro-6-(methylsulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine
  • 3-Butyl-1-methyl-1H-imidazol-3-ium tetrabromoferrate(III)
  • Rel-2-((4aR,8aR)-decahydronaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • (S)-2-Amino-4-(3-chloro-4-(trifluoromethyl)phenyl)butanoic acid