Asiaticoside

Names

[ Name ]:
Asiaticoside

[Synonym ]:
dermatologico
MADESOL
Ba-2742
CENTELASE
asiaticosid
MFCD06642601
EMdesol
MADEOL
EINECS 240-851-7
Martisol
scheffursoside F

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
949.4±65.0 °C at 760 mmHg

[ Melting Point ]:
235-238ºC

[ Molecular Formula ]:
C₄₈H₇₈O₁₉

[ Molecular Weight ]:
959.12

[ Flash Point ]:
268.4±27.8 °C

[ PSA ]:
315.21000

[ LogP ]:
8.34

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.606

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU9625000

CHEMICAL NAME :: Urs-12-en-28-oic acid, 2-alpha,3-beta,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl- (1-4)-o-beta-D-glucopyranosyl-(1-6)-o-beta-D-glucopyr anosyl ester

CAS REGISTRY NUMBER :: 16830-15-2

BEILSTEIN REFERENCE NO. :: 0078195

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C48-H78-O19

MOLECULAR WEIGHT :: 959.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 32,1463,1972 *** REVIEWS *** TOXICOLOGY REVIEW CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YU9625000

Precursor & DownStream

Precursor

DownStream

Articles

In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.

J. Ethnopharmacol. 130(2) , 275-83, (2010)

Centella asiatica (CA) has been widely cultivated as a vegetable or spice in China, Southeast Asia, India, Sri Lanka, Africa, and Oceanic countries and traditionally used for wound healing and maintai...

Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.

Pharm. Biol. 50(12) , 1508-12, (2012)

Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asitica (L.) Urban. (Apiaceae). These compounds possess various ...

Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica.

Pharm. Biol. 51(9) , 1182-7, (2013)

Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases.Centella asiatica methanol extract and it...