oxymatrine

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Names

[ CAS No. ]:
16837-52-8

[ Name ]:
oxymatrine

[Synonym ]:
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]naphthyridin-10-one 4-oxide
(4R,7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]naphthyridin-10-one 4-oxide
Ammothamnine
Matrine N-oxide
(7aS,13aR,13bR,13cS)Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (7aS,13aR,13bR,13cS)-
Oxymatrine

Chemical & Physical Properties

[ Molecular Formula ]:
C15H24N2O2

[ Molecular Weight ]:
264.363

[ Exact Mass ]:
264.183777

[ PSA ]:
49.74000

[ LogP ]:
-0.35

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Water Solubility ]:
methanol: soluble10mg/mL, clear, colorless

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OQ1770000
CHEMICAL NAME :
Matrine, 1-oxide
CAS REGISTRY NUMBER :
16837-52-8
LAST UPDATED :
199412
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C15-H24-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
521 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18(7),23,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 18,2555,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
257 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-20/22

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
OQ1770000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Matrine

DownStream

  • Matrine

Articles

Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.

Cancer Chemother. Pharmacol. 75(2) , 353-63, (2015)

Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of the quinolizidine alkaloid compounds extracted from the root of Sophora flavescens (a traditional Chinese herb). Oxymatrine has b...

Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.

Biochem. Pharmacol. 84(6) , 830-7, (2012)

Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of ...

Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.

CNS Neurosci. Ther. 18(12) , 1030-2, (2012)


More Articles

Related Compounds

  • Oxymatrine
  • OXYMATRINE
  • OXYMATRINE(P)
  • (2,3,4-Trimethoxy-phenyl)-carbamic acid tert-butyl ester
  • 2-methyl-4-(1-methyl-1H-indol-5-yl)pyrimidine-5-carboxylic acid
  • N-cyclohexyl-N-methyl-2-(propylamino)benzamide
  • 5-(Pyrimidin-4-yl)oxazole
  • ethyl 2-methyl-4-(1-methyl-1H-indol-5-yl)pyrimidine-5-carboxylate
  • 2-Methyl-1-(3,3,3-trifluoropropyl)piperidin-4-amine
  • (3,3,3-Trifluoropropyl)glycine
  • 6-chloro-N-(3,3,3-trifluoropropyl)nicotinamide
  • 1-[2-[(Difluoromethyl)thio]phenyl]piperazine
  • 1-Benzyl-3-isocyanatopiperidine
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