GR 203040
Suppliers
Names
[ CAS No. ]:
168398-02-5
[ Name ]:
GR 203040
[Synonym ]:
3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,hydrochloride(1:2),(2S,3S)
3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,dihydrochloride,(2S-cis)
3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,dihydrochloride,(2S,3S)-(9CI)
Chemical & Physical Properties
[ Boiling Point ]:
560.4ºC at 760mmHg
[ Molecular Formula ]:
C20H26Cl2N6O
[ Molecular Weight ]:
437.37
[ Flash Point ]:
292.7ºC
[ Exact Mass ]:
364.20100
[ PSA ]:
76.89000
[ LogP ]:
2.97350
[ Vapour Pressure ]:
1.37E-12mmHg at 25°C
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
Pharmacol. Biochem. Behav. 79(1) , 125-35, (2004)
Mu-, kappa- and delta-opioid receptor agonists are reported to attenuate the acetic-acid-induced abdominal constriction response in mice. NK-1, -2 and -3 receptor antagonists also display activity in ...
Neuropharmacology 39(4) , 664-70, (2000)
Two high affinity and selective NK1-receptor antagonists, GR203040 and GR205171, were labelled with 11C and used in a series of experiments in rhesus monkeys. The purpose of these studies was to evalu...
Br. J. Pharmacol. 116(8) , 3158-63, (1995)
1. Following our earlier observations that the tachykinin NK1 receptor antagonist CP-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel ...