Tacrine hydrochloride
Suppliers
Names
[ CAS No. ]:
1684-40-8
[ Name ]:
Tacrine hydrochloride
[Synonym ]:
1,2,3,4-Tetrahydroacridin-9-amine hydrochloride (1:1)
1,2,3,4-Tetrahydroacridin-9-aminhydrochlorid
9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride, hydrate (1:1:2)
1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Cognex
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate
1,2,3,4-Tetrahydro-9-acridinamine hydrochloride (1:1)
THA
1,2,3,4-tetrahydroacridin-9-amine,hydrochloride
1,2,3,4-Tetrahydro-9-acridinamine hydrochloride dihydrate
EINECS 216-867-5
MFCD00012657
9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1)
1,2,3,4-tétrahydroacridin-9-amine chlorhydrate
Tacrin hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
409.4ºC at 760mmHg
[ Melting Point ]:
280-284 °C(lit.)
[ Molecular Formula ]:
C13H15ClN2
[ Molecular Weight ]:
270.755
[ Flash Point ]:
230.5ºC
[ Exact Mass ]:
270.113495
[ PSA ]:
38.91000
[ LogP ]:
4.07900
[ Vapour Pressure ]:
6.49E-07mmHg at 25°C
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AR9532500
- CHEMICAL NAME :
- Acridine, 1,2,3,4-tetrahydro-9-amino-, monohydrochloride
- CAS REGISTRY NUMBER :
- 1684-40-8
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C13-H14-N2.Cl-H
- MOLECULAR WEIGHT :
- 234.75
- WISWESSER LINE NOTATION :
- T C666 BN&&TJ IZ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 10,638,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07602
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H319-H335
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P305 + P351 + P338
[ Hazard Codes ]:
T: Toxic;Xn: Harmful;
[ Risk Phrases ]:
25-36/37/38-20/22
[ Safety Phrases ]:
S26-S36-S45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
AR9532500
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%