Celecoxib

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Names

[ CAS No. ]:
169590-42-5

[ Name ]:
Celecoxib

[Synonym ]:
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
Celebra
Celecoxib
1-(4-sulphamoylphenyl)-3-trifluoromethyl-5-(p-tolyl)-pyrazole
MFCD00941298
Celecox
YM 177
Benzenesulfonamide, 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-
Solexa
Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide
4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-ylbenzenesulfonamide
benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
Celocoxib
Celebrex
N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]phenylsulfonyl]benzensulfonamide
celexicob
Celebrex,Celebra

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
529.0±60.0 °C at 760 mmHg

[ Melting Point ]:
157-159ºC

[ Molecular Formula ]:
C17H14F3N3O2S

[ Molecular Weight ]:
381.372

[ Flash Point ]:
273.7±32.9 °C

[ Exact Mass ]:
381.075867

[ PSA ]:
86.36000

[ LogP ]:
4.21

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.606

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360D

[ Precautionary Statements ]:
P201-P308 + P313

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25-S28-S37/39

[ RIDADR ]:
UN 2811

[ RTECS ]:
DB2944937

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-Butanedione, 4,4,4-trifluoro-1-p-tolyl-
  • 4-Hydrazinobenzene-1-sulfonamide hydrochloride
  • N,N-dibenzyl-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
  • Ethyl trifluoroacetate
  • 4'-Methylacetophenone
  • 4-Hydrazinobenzenesulfonamide
  • 1,1,1-trifluoro-4-(4-methylphenyl)but-3-en-2-one
  • celecoxib DMF solvate
  • 1:1 Celecoxib:DMA adduct

DownStream

  • Hydroxy Celecoxib

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.

Br. J. Pharmacol. 172 , 3028-42, (2015)

Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved ...

Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1.

J. Virol. 89(4) , 2268-86, (2015)

Nuclear factor erythroid 2-related factor 2 (Nrf2), the cellular master regulator of the antioxidant response, dissociates from its inhibitor Keap1 when activated by stress signals and participates in...

Celecoxib inhibits Ewing sarcoma cell migration via actin modulation.

J. Surg. Res. 198 , 424-33, (2015)

Ewing sarcoma (ES) is an aggressive childhood solid tumor in which 30% of cases are metastatic at presentation, and subsequently carry a poor prognosis. We have previously shown that treatment with ce...


More Articles

Related Compounds

  • Celecoxib
  • CELECOXIB
  • Celecoxib
  • celecoxib
  • Celecoxib-d4
  • Hydroxy Celecoxib
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine