Alvimopan

Suppliers

Names

[ Name ]:
Alvimopan

[Synonym ]:
Alvimopan dihydrate
Alvimopan
N-{(2S)-2-Benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]propanoyl}glycine dihydrate
Glycine, N-[(2S)-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]-1-oxo-2-(phenylmethyl)propyl]-, hydrate (1:2)
Alvimopan (USAN)
Adl 8-2698
Alvimopan anhydrous
UNII-677C126AET
Alvimopan hydrate
Entereg
Alvimopan (dihydrate)

Chemical & Physical Properties

[ Density]:
1.166g/cm3

[ Boiling Point ]:
684.1ºC at 760mmHg

[ Melting Point ]:
210-213ºC

[ Molecular Formula ]:
C₂₅H₃₆N₂O₆

[ Molecular Weight ]:
460.563

[ Flash Point ]:
367.5ºC

[ Exact Mass ]:
460.257324

[ PSA ]:
108.33000

[ LogP ]:
3.25160

[ Vapour Pressure ]:
1.18E-19mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0595275

CHEMICAL NAME :: Glycine, N-(2-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl )methyl)-1-oxo-3-phen ylpropyl)-,dihydrate, (3R-(1(S*),3-alpha,4-alpha))-

CAS REGISTRY NUMBER :: 170098-38-1

LAST UPDATED :: 199606

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H32-N2-O4.2H2-O

MOLECULAR WEIGHT :: 460.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994