Donitriptan monohydrochloride

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Names

[ CAS No. ]:
170911-68-9

[ Name ]:
Donitriptan monohydrochloride

[Synonym ]:
Donitriptan hydrochloride
Donitriptan monohydrochloride
Nafadotride

Chemical & Physical Properties

[ Boiling Point ]:
727.1ºC at 760 mmHg

[ Molecular Formula ]:
C23H26ClN5O2

[ Molecular Weight ]:
439.94

[ Flash Point ]:
393.6ºC

[ Exact Mass ]:
439.17800

[ PSA ]:
98.38000

[ LogP ]:
3.77358

[ Vapour Pressure ]:
5.34E-21mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 3439 6.1 / PGIII

Articles

Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.

Br. J. Pharmacol. 149(1) , 82-91, (2006)

It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nocice...

Donitriptan (Pierre Fabre).

Curr. Opin. Investig. Drugs 2(3) , 415-8, (2001)

Pierre Fabre is developing donitriptan, a piperazide 5-HT1D agonist, as a potential treatment for migraine [175854]. In January 2001, donitriptan had completed phase I trials for migraine and was sche...

Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.

Cephalalgia 22(1) , 37-47, (2002)

We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.1...


More Articles

Related Compounds

  • Donitriptan
  • HYPOXANTHINE MONOHYDROCHLORIDE, [8-3H]
  • Nilotinib monohydrochloride monohydrate
  • Trimethylammonium monohydrochloride
  • Hydroxocobalamin monohydrochloride
  • butylguanidine monohydrochloride
  • (E)-1-(4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidin-1-yl)-3-phenylprop-2-en-1-one
  • 1-(4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidin-1-yl)-2-phenoxyethanone
  • 2-(2-fluorophenoxy)-1-(4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidin-1-yl)ethanone
  • N-(2-(benzo[d][1,3]dioxol-5-yl)-2-hydroxypropyl)thiophene-3-carboxamide
  • 3-(2-Benzoxazolyl)-1-(4-hydroxy-1-piperidinyl)-2-propen-1-one
  • (5-bromofuran-2-yl)(4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidin-1-yl)methanone
  • N-(2-(benzo[d][1,3]dioxol-5-yl)-2-hydroxypropyl)-2-(4-fluorophenyl)acetamide
  • (4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidin-1-yl)(thiophen-2-yl)methanone
  • 3-(4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidine-1-carbonyl)-2H-chromen-2-one
  • N-(2-(benzo[d][1,3]dioxol-5-yl)-2-hydroxypropyl)-2-(2,5-dioxopyrrolidin-1-yl)acetamide
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