Donitriptan monohydrochloride

[ Boiling Point ]:
727.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₆ClN₅O₂

[ Molecular Weight ]:
439.94

[ Flash Point ]:
393.6ºC

[ Exact Mass ]:
439.17800

[ PSA ]:
98.38000

[ LogP ]:
3.77358

[ Vapour Pressure ]:
5.34E-21mmHg at 25°C

[ Storage condition ]:
2-8°C

Click to get detail MSDS

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 3439 6.1 / PGIII

Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.

Br. J. Pharmacol. 149(1) , 82-91, (2006)

It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nocice...

Donitriptan (Pierre Fabre).

Curr. Opin. Investig. Drugs 2(3) , 415-8, (2001)

Pierre Fabre is developing donitriptan, a piperazide 5-HT1D agonist, as a potential treatment for migraine [175854]. In January 2001, donitriptan had completed phase I trials for migraine and was sche...

Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.

Cephalalgia 22(1) , 37-47, (2002)

We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.1...

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