(2R,3S)-2-[(1R)-1-[3,5-bis(Trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine

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Names

[ CAS No. ]:
171338-27-5

[ Name ]:
(2R,3S)-2-[(1R)-1-[3,5-bis(Trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Chemical & Physical Properties

[ Density]:
1.375 g/cm3

[ Boiling Point ]:
387.856ºC at 760 mmHg

[ Molecular Formula ]:
C20H18F7NO2

[ Molecular Weight ]:
437.35100

[ Flash Point ]:
188.369ºC

[ Exact Mass ]:
437.12300

[ PSA ]:
30.49000

[ LogP ]:
5.99300

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.505

Synthetic Route

Precursor & DownStream

Precursor

  • (6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine
  • 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine
  • 4-Fluorophenylmagnesium bromide
  • (2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one
  • (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
  • 1-(3,5-Bis(trifluoromethyl)phenyl)ethanone
  • 4-Benzyl-2,3-Morpholinedione
  • 2-(Benzylamino)ethanol
  • 4-Benzyl-2-hydroxy-3-morpholinone

DownStream

  • Aprepitant

Related Compounds

  • 1-(5-Bromo-6-methoxypyridin-2-yl)pyrrolidin-3-ol
  • Methyl 6-chloro-5-(6-(3-hydroxypyrrolidin-1-yl)-2-methoxypyridin-3-yl)-1h-indole-3-carboxylate
  • 6-chloro-5-[4-(propan-2-yl)phenyl]-1H-indole-3-carbaldehyde
  • 5-(4-chlorophenyl)-3,4-dihydro-2H-pyran
  • 5-bromo-6-chloro-N-(methylsulfonyl)-1H-indole-3-carboxamide
  • ((2-(4-Iodophenoxy)propoxy)methanetriyl)tribenzene
  • 2-(4-Iodophenoxy)propan-1-ol
  • (S)-1-(5-Bromo-6-methoxypyridin-2-yl)pyrrolidin-3-ol
  • 5-cyclopropyl-2-methyl-3H,4H-thieno[2,3-d]pyrimidin-4-one
  • 4-Chloro-5-cyclopropyl-2-methylthieno[2,3-D]pyrimidine
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