Mosher's acid

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Names

[ Name ]:
Mosher's acid

[Synonym ]:
(S)-(-)-α-Methoxy-α-(trifluoroMethyl)phenylacetic Acid [Optical Resolving]
Mosher's acid
MFCD00064200
Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αS)-
mtpa
(S)-Mosher's Acid
(±)-Mosher's acid
a-Methoxy-a-(trifluoromethyl)phenylacetic Acid
(-)-Mosher's acid
UNII:E015GCC0MA
(−)-MTPA
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
(±)-MTPA
3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid
EINECS 241-292-1
(2S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid
α-methoxy-α-trifluoromethylphenylacetic acid
(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid
(S)-(-)-MTPA
Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-
Methoxy (trifluoromethyl)phenylacetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
287.2±0.0 °C at 760 mmHg

[ Melting Point ]:
46-49ºC

[ Molecular Formula ]:
C₁₀H₉F₃O₃

[ Molecular Weight ]:
234.172

[ Flash Point ]:
134.2±27.3 °C

[ Exact Mass ]:
234.050385

[ PSA ]:
46.53000

[ LogP ]:
3.79

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.470

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,2,2-Trifluoroacetophenone
(E)-1,1,1-trifluoro-3-(((S)-2-(methoxydiphenylmethyl)pyrrolidin-1-yl)imino)-2-phenylpropan-2-ol
(S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one
(S)-3,3,3-trifluoro-2-hydroxy-2-phenylpropanoic acid
(R)-(+)-Mosher's acid

DownStream

(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride
1,3-Diisopropylurea
(S)-((R)-4-phenylbutan-2-yl) 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

[Three dimensional structure analysis of organic chemical compounds from natural sources using NMR spectral analysis].

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho. Hokoku. (121) , 87-8, (2003)

Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.

Nat. Protoc. 2 , 2451-2458, (2007)

This protocol details the most commonly used nuclear magnetic resonance (NMR)-based method for deducing the configuration of otherwise unknown stereogenic, secondary carbinol (alcohol) centers (R1R2CH...

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.

Nat. Neurosci. 8(11) , 1481-9, (2005)

Drug addiction is increasingly viewed as the endpoint of a series of transitions from initial drug use--when a drug is voluntarily taken because it has reinforcing, often hedonic, effects--through los...

Mosher's acid
R-Mosher's acid
Mosher's acid chloride
Mosher's acid chloride
Mosher's acid chloride
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