Tazettine,6a-deoxy-8-hydroxy-, hydrochloride, (6ab,8b)- (9CI)

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Names

[ CAS No. ]:
17322-85-9

[ Name ]:
Tazettine,6a-deoxy-8-hydroxy-, hydrochloride, (6ab,8b)- (9CI)

[Synonym ]:
isotazettine,hydrochloride
(3s,4as,6ar,8r,13bs)-3-methoxy-5-methyl-3,4,4a,5,6,6a-hexahydro-8h-[1,3]dioxolo[6,7]isochromeno[3,4-c]indol-8-ol
Tazettine,6a-deoxy-8-hydroxy-,(6abeta,8beta)
(+)-pretazettine
Pretazettin
isotazettine
pratazettine hydrochloride
Pretazettin-hydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
499.6ºC at 760mmHg

[ Molecular Formula ]:
C18H22ClNO5

[ Molecular Weight ]:
367.82400

[ Flash Point ]:
255.9ºC

[ Exact Mass ]:
367.11900

[ PSA ]:
60.39000

[ LogP ]:
2.07160

[ Vapour Pressure ]:
8.45E-11mmHg at 25°C

[ Index of Refraction ]:
1.656

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU7500000
CHEMICAL NAME :
Pretazettine, hydrochloride
CAS REGISTRY NUMBER :
17322-85-9
LAST UPDATED :
198207
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H21-N-O5.Cl-H
MOLECULAR WEIGHT :
367.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958- Volume(issue)/page/year: 24,259,1981

Related Compounds

  • 3-(3,5-Dimethylphenyl)isoquinoline
  • 5-Chloro-1-methyl-1H-pyrazolo[4,3-b]pyridine
  • 3-Cyclohexylbicyclo[1.1.1]pentane-1-carboxylic acid
  • 5-[4-(2-Methoxyethyl)piperidin-4-yl]-3-methyl-1,2,4-oxadiazole
  • 5-(3-Ethyl-1,2,4-oxadiazol-5-yl)-2-oxa-7-azaspiro[3.4]octane
  • 8-(4-Methoxy-2,5-dimethylphenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-one
  • 3-[3-(2-Methoxyphenyl)phenyl]piperazin-2-one
  • 3-[3-(1,5-Dimethylpyrazol-4-yl)phenyl]piperazin-2-one
  • 6-Phenylspiro[1,2-dihydroindene-3,2'-cyclopropane]-1'-carboxylic acid
  • 6-(2-Methoxyphenyl)spiro[1,2-dihydroindene-3,2'-cyclopropane]-1'-carboxylic acid
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