Aliskiren hemifumarate

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Names

[ CAS No. ]:
173334-58-2

[ Name ]:
Aliskiren hemifumarate

[Synonym ]:
CGP60536B
Aliskiren fumarate
tekturna
(2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide (2E)-2-butenedioate (2:1)
Aliskiren hemifumarate
(2E)-But-2-endisäure--(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamid(1:2)
Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1) (salt)
CGP 60536
(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide (2E)-but-2-enedioate (2:1) (salt)
Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1
 ) (salt)
acide (2E)-but-2-ènedioïque - (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-diméthyl-3-oxopropyl)-4-hydroxy-7-[4-méthoxy-3-(3-méthoxypropoxy)benzyl]-8-méthyl-2-(1-méthyléthyl)nonanamide (1:2)
Rasilez
SPP 100
(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide hemifumarate
benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1
Aliskirenhemifumarate
Aliskiren (hemifumarate)

Chemical & Physical Properties

[ Melting Point ]:
72-75?C

[ Molecular Formula ]:
C64H110N6O16

[ Molecular Weight ]:
1219.59000

[ Exact Mass ]:
1218.80000

[ PSA ]:
366.86000

[ LogP ]:
9.88180

[ Vapour Pressure ]:
1.59E-23mmHg at 25°C

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Precursor & DownStream

Precursor

  • δN-Benzyloxycarbonyl Aliskiren
  • fumaric acid
  • tert-butyl N-[(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-2,9-dimethyldecan-5-yl]carbamate
  • Aliskiren
  • Aliskiren Hydrochloride
  • BenzeneoctanaMide
  • 3-Amino-2,2-dimethylpropanamide
  • 3-Methylbutanoic acid
  • 3-Amino-2,2-dimethylpropanenitrile
  • 2-cyano-2-methyl-propanamide

DownStream

  • Aliskiren

Related Compounds

  • Aliskiren D6 Hydrochloride
  • Aliskiren Carboxylic Acid
  • Aliskiren Hydrochloride
  • Aliskiren
  • Aliskiren fumarate
  • Aliskiren inter-10
  • 3-Bromo-1-[(oxan-4-yl)methyl]-1,2-dihydropyridin-2-one
  • 3-Ethyl-1-[(3-hydroxypyrrolidin-3-yl)methyl]urea
  • Methyl N-[(3-hydroxy-3-pyrrolidinyl)methyl]carbamate
  • 1-[(3-Hydroxypyrrolidin-3-yl)methyl]-3-(propan-2-yl)urea
  • (4-Methylmorpholin-2-yl)methanesulfonyl chloride
  • (R)-tert-butyl(2-fluoro-3-hydroxy-3-methylbutyl)carbamate
  • (2-oxo-3H-1-benzofuran-6-yl)boronic acid
  • 3-Methyl-6-nitro-1-benzothiophene
  • 7-Methyl-N-[2-(4-morpholinyl)ethyl]-1H-indole-2-carboxamide
  • N2-Ethyl-5-iodo-2,3-pyridinediamine
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