Cerulenin
Suppliers
Names
[ CAS No. ]:
17397-89-6
[ Name ]:
Cerulenin
[Synonym ]:
2,3-Epoxy-4-oxo-7,10-dodecadienamide
(2R,3S)-3-[(4E,7E)-Nona-4,7-dienoyl]oxirane-2-carboxamide
trans-dodecadienamide)
3S)-2,3-epoxy-4-oxo-7,10-trans
caerulein A
EINECS 241-424-8
[2R-[2a,3a(4E,7E)]]-3-(1-Oxo-4,7-nonadienyl)oxiranecarboxamide
Oxiranecarboxamide, 3-(1-oxo-4,7-nonadienyl)-, (2R-(2-α,3-α(4E,7E)))- (9CI)
(2R,3S)-3-[(4E,7E)-4,7-Nonadienoyl]-2-oxiranecarboxamide
2-Oxiranecarboxamide, 3-[(4E,7E)-1-oxo-4,7-nonadien-1-yl]-, (2R,3S)-
Helicocerin
MFCD00077686
2-Oxiranecarboximidic acid, 3-[(4E,7E)-1-oxo-4,7-nonadien-1-yl]-, (2R,3S)-
(2R,3S)-3-[(4E,7E)-4,7-Nonadienoyl]-2-oxiranecarboximidic acid
Cerulenin
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
456.1±45.0 °C at 760 mmHg
[ Melting Point ]:
93.5℃
[ Molecular Formula ]:
C12H17NO3
[ Molecular Weight ]:
223.268
[ Flash Point ]:
241.1±25.0 °C
[ Exact Mass ]:
223.120850
[ PSA ]:
72.69000
[ LogP ]:
0.94
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.529
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JR1670000
- CHEMICAL NAME :
- 7,10-Dodecadienamide, 2,3-epoxy-4-oxo-
- CAS REGISTRY NUMBER :
- 17397-89-6
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C12-H17-N-O3
- MOLECULAR WEIGHT :
- 223.30
- WISWESSER LINE NOTATION :
- T3OTJ BVZ CV2U4U2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 547 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 211 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 154 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 2 mg/L
- REFERENCE :
- JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 133,472,1978
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
JR1670000
Articles
Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)
Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...
PLoS ONE 9(6) , e101060, (2014)
The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human canc...
MBio 6 , e00581, (2015)
Multicellular biofilm formation and surface motility are bacterial behaviors considered mutually exclusive. However, the basic decision to move over or stay attached to a surface is poorly understood....