(S)-(+)-2-Hydroxy-3-Methylbutyric acid

Suppliers

Names

[ Name ]:
(S)-(+)-2-Hydroxy-3-Methylbutyric acid

[Synonym ]:
MFCD00066443
A-hydroxyisovaleric acid
DL-2-Hydroxyisovaleric acid
2-Hydroxy-3-methylbutanoic acid
DL-2-Hydroxy-3-methylbutanoic acid
2-Hydroxy-3-methylbutyric acid
α-hydroxyisovaleric acid
3-Methyl-2-hydroxybutyric acid
Butanoic acid, 2-hydroxy-3-methyl-
2-Hydroxyisopentanoic acid
UNII:02X1W97FWN
DL-a-hydroxyisovaleric acid
(2R)-2-Hydroxy-3-methylbutanoic acid
Butanoic acid, 2-hydroxy-3-methyl-, (2R)-
2-hydroxyisovaleric acid
DL-α-hydroxyisovaleric acid
2-hydroxy-3-methyl-Butyric acid

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
237.6±13.0 °C at 760 mmHg

[ Melting Point ]:
68-70ºC(lit.)

[ Molecular Formula ]:
C₅H₁₀O₃

[ Molecular Weight ]:
118.131

[ Flash Point ]:
111.8±16.3 °C

[ Exact Mass ]:
118.062996

[ PSA ]:
57.53000

[ LogP ]:
0.18

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.455

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

(S)-tert-Butyl 2-hydroxy-3-methylbutanoate
2-trimethylsilylethyl (2S)-2-hydroxy-3-methylbutanoate
(2S)-N-benzyl-2-hydroxy-3-methylbutanamide
(S)-Methyl 2-hydroxy-3-methyl butanoate
H-D-Val-OMe.HCl
Butanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-3-methyl-, (2R)-
prop-2-enyl (2S)-2-hydroxy-3-methylbutanoate
(2R)-2-[tert-butyl(dimethyl)silyl]oxy-3-methylbutanoic acid
(2S)-2-hydroxy-2,3-dimethylbutanoic acid
(2S)-2-Isopropyloxirane

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

Brain Res. 1324 , 75-84, (2010)

Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathoiphysiology is poorly known. In the present study we investigated the in ...

Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.

J. Biol. Chem. 282 , 23841-53, (2007)

Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine thei...

Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.

J. Chromatogr. A. 874(1) , 91-100, (2000)

An efficient method is described for the simultaneous enantiomeric separation of 18 different racemic 2-hydroxy acids for the determination of their absolute configurations. It involves the conversion...

(S)-(+)-2-hydroxy-3-methylbutyric acid benzyl ester
(S)-(+)-2-Methylbutyric acid acid p-bromophenacyl ester
2(S)-(+)-(2-chloromethylquinazolin-4-ylamino)-3-methylbutyric acid methyl ester
(S)-(-)-2-AMINO-3,3-DIMETHYL-1,1-DIPHENYL-1-BUTANOL
(±)-2-hydroxy-3-methylbutyric acid
(S)-2-(4-methoxyphenyl)-3-methylbutyric acid